4yoo
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==p107 pocket domain in complex with LIN52 P29A peptide== |
| - | + | <StructureSection load='4yoo' size='340' side='right' caption='[[4yoo]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yoo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YOO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gux|1gux]], [[4yoz|4yoz]], [[4yos|4yos]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yoo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yoo RCSB], [http://www.ebi.ac.uk/pdbsum/4yoo PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/RBL1_HUMAN RBL1_HUMAN]] Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Felthousen, J G]] | ||
| + | [[Category: Guiley, K Z]] | ||
| + | [[Category: Liban, T J]] | ||
[[Category: Litovchick, L]] | [[Category: Litovchick, L]] | ||
| - | [[Category: | + | [[Category: Ramanan, P]] |
| - | [[Category: | + | [[Category: Rubin, S M]] |
[[Category: Tripathi, S]] | [[Category: Tripathi, S]] | ||
| + | [[Category: Cyclin box pocket protein transcriptional regulator cell cycle]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 12:26, 13 May 2015
p107 pocket domain in complex with LIN52 P29A peptide
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