4z31
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the RC3H2 ROQ domain in complex with stem-loop and double-stranded forms of RNA== |
| - | + | <StructureSection load='4z31' size='340' side='right' caption='[[4z31]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4z31]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z31 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z31 OCA], [http://pdbe.org/4z31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z31 RCSB], [http://www.ebi.ac.uk/pdbsum/4z31 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | + | [[http://www.uniprot.org/uniprot/RC3H2_HUMAN RC3H2_HUMAN]] Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
| - | [[Category: | + | [[Category: DONG, A]] |
| - | [[Category: | + | [[Category: Edwards, A M]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: TEMPEL, W]] |
| - | [[Category: | + | [[Category: TONG, Y]] |
| - | [[Category: | + | [[Category: ZHANG, Q]] |
| + | [[Category: Rna]] | ||
| + | [[Category: Rna binding protein-rna complex]] | ||
| + | [[Category: Roquin2]] | ||
| + | [[Category: Sgc]] | ||
Revision as of 04:04, 16 October 2015
Crystal structure of the RC3H2 ROQ domain in complex with stem-loop and double-stranded forms of RNA
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Categories: Arrowsmith, C H | Bountra, C | DONG, A | Edwards, A M | Structural genomic | TEMPEL, W | TONG, Y | ZHANG, Q | Rna | Rna binding protein-rna complex | Roquin2 | Sgc
