2v9y

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|PDB= 2v9y |SIZE=350|CAPTION= <scene name='initialview01'>2v9y</scene>, resolution 2.10&Aring;
|PDB= 2v9y |SIZE=350|CAPTION= <scene name='initialview01'>2v9y</scene>, resolution 2.10&Aring;
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+B'>AC2</scene> and <scene name='pdbsite=AC3:So4+Binding+Site+For+Chain+B'>AC3</scene>
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+B'>AC2</scene> and <scene name='pdbsite=AC3:So4+Binding+Site+For+Chain+B'>AC3</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span>
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1mej|1MEJ]], [[1men|1MEN]], [[1meo|1MEO]], [[1zly|1ZLY]], [[1njs|1NJS]], [[1zlx|1ZLX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB]</span>
}}
}}
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[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
[[Category: Welin, M.]]
[[Category: Welin, M.]]
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[[Category: SO4]]
 
[[Category: air]]
[[Category: air]]
[[Category: alternative splicing]]
[[Category: alternative splicing]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:44:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:10:11 2008''

Revision as of 02:10, 31 March 2008

Image:2v9y.jpg


PDB ID 2v9y

Drag the structure with the mouse to rotate
, resolution 2.10Å
Sites: , and
Ligands:
Activity: Phosphoribosylformylglycinamidine cyclo-ligase, with EC number 6.3.3.1
Related: 1MEJ, 1MEN, 1MEO, 1ZLY, 1NJS, 1ZLX


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE


Overview

We tested the general applicability of in situ proteolysis to form protein crystals suitable for structure determination by adding a protease (chymotrypsin or trypsin) digestion step to crystallization trials of 55 bacterial and 14 human proteins that had proven recalcitrant to our best efforts at crystallization or structure determination. This is a work in progress; so far we determined structures of 9 bacterial proteins and the human aminoimidazole ribonucleotide synthetase (AIRS) domain.

About this Structure

2V9Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

In situ proteolysis for protein crystallization and structure determination., Dong A, Xu X, Edwards AM, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Graslund S, Hammerstrom M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H, Nat Methods. 2007 Dec;4(12):1019-21. Epub 2007 Nov 4. PMID:17982461

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