2vdb
From Proteopedia
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|PDB= 2vdb |SIZE=350|CAPTION= <scene name='initialview01'>2vdb</scene>, resolution 2.515Å | |PDB= 2vdb |SIZE=350|CAPTION= <scene name='initialview01'>2vdb</scene>, resolution 2.515Å | ||
|SITE= <scene name='pdbsite=AC1:Dka+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Dka+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Dka+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Dka+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Dka+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Dka+Binding+Site+For+Chain+A'>AC6</scene> and <scene name='pdbsite=AC7:Nps+Binding+Site+For+Chain+A'>AC7</scene> | |SITE= <scene name='pdbsite=AC1:Dka+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Dka+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Dka+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Dka+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Dka+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Dka+Binding+Site+For+Chain+A'>AC6</scene> and <scene name='pdbsite=AC7:Nps+Binding+Site+For+Chain+A'>AC7</scene> | ||
| - | |LIGAND= <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene> | + | |LIGAND= <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=NPS:(2S)-2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOIC+ACID'>NPS</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1bm0|1BM0]], [[1e7a|1E7A]], [[1e7e|1E7E]], [[1e7g|1E7G]], [[1gni|1GNI]], [[1h9z|1H9Z]], [[1ha2|1HA2]], [[1hk1|1HK1]], [[1hk4|1HK4]], [[1hk5|1HK5]], [[1tf0|1TF0]], [[1uor|1UOR]], [[1ysx|1YSX]], [[2bx8|2BX8]], [[2bxa|2BXA]], [[2bxb|2BXB]], [[2bxc|2BXC]], [[2bxd|2BXD]], [[2bxi|2BXI]], [[2bxo|2BXO]], [[2bxq|2BXQ]], [[1ao6|1AO6]], [[1bj5|1BJ5]], [[1bke|1BKE]], [[1e78|1E78]], [[1e7b|1E7B]], [[1e7c|1E7C]], [[1e7f|1E7F]], [[1e7h|1E7H]], [[1e7i|1E7I]], [[1gnj|1GNJ]], [[1hk2|1HK2]], [[1hk3|1HK3]], [[1n5u|1N5U]], [[1o9x|1O9X]], [[2bxe|2BXE]], [[2bxf|2BXF]], [[2bxg|2BXG]], [[2bxh|2BXH]], [[2bxk|2BXK]], [[2bxl|2BXL]], [[2bxm|2BXM]], [[2bxn|2BXN]], [[2bxp|2BXP]], [[2esg|2ESG]], [[1gab|1GAB]], [[1prb|1PRB]], [[2j5y|2J5Y]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vdb OCA], [http://www.ebi.ac.uk/pdbsum/2vdb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vdb RCSB]</span> | ||
}} | }} | ||
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[[Category: Lejon, S.]] | [[Category: Lejon, S.]] | ||
[[Category: Nordberg, P A.]] | [[Category: Nordberg, P A.]] | ||
| - | [[Category: DKA]] | ||
| - | [[Category: NPS]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: bacterial albumin-binding]] | [[Category: bacterial albumin-binding]] | ||
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[[Category: three-helix bundle]] | [[Category: three-helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:11:09 2008'' |
Revision as of 02:11, 31 March 2008
| |||||||
| , resolution 2.515Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , and | ||||||
| Ligands: | , | ||||||
| Related: | 1BM0, 1E7A, 1E7E, 1E7G, 1GNI, 1H9Z, 1HA2, 1HK1, 1HK4, 1HK5, 1TF0, 1UOR, 1YSX, 2BX8, 2BXA, 2BXB, 2BXC, 2BXD, 2BXI, 2BXO, 2BXQ, 1AO6, 1BJ5, 1BKE, 1E78, 1E7B, 1E7C, 1E7F, 1E7H, 1E7I, 1GNJ, 1HK2, 1HK3, 1N5U, 1O9X, 2BXE, 2BXF, 2BXG, 2BXH, 2BXK, 2BXL, 2BXM, 2BXN, 2BXP, 2ESG, 1GAB, 1PRB, 2J5Y
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF HUMAN SERUM ALBUMIN WITH S-NAPROXEN AND THE GA MODULE
Overview
The previously determined crystal structure of the bacterial albumin-binding GA module in complex with human serum albumin (HSA) suggested the possibility of utilizing the complex in the study of ligand binding to HSA. As a continuation of these studies, the crystal structure of the HSA-GA complex with the drug molecule naproxen and the fatty acid decanoate bound to HSA has been determined to a resolution of 2.5 A. In terms of drug binding, the structure suggests that the binding of decanoate to the albumin molecule may play a role in making the haemin site in subdomain IB of the albumin molecule available for the binding of naproxen. In addition, structure comparisons with solved structures of HSA and of the HSA-GA complex show that the GA module is capable of binding to different conformations of HSA. The HSA-GA complex therefore emerges as a possible platform for the crystallographic study of specific HSA-drug interactions and of the influence exerted by the presence of fatty acids.
About this Structure
2VDB is a Protein complex structure of sequences from Finegoldia magna and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for the binding of naproxen to human serum albumin in the presence of fatty acids and the GA module., Lejon S, Cramer JF, Nordberg P, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Feb 1;64(Pt, 2):64-9. Epub 2008 Jan 18. PMID:18259051
Page seeded by OCA on Mon Mar 31 05:11:09 2008
Categories: Finegoldia magna | Homo sapiens | Protein complex | Cramer, J F. | Lejon, S. | Nordberg, P A. | Alternative splicing | Bacterial albumin-binding | Cell wall | Cleavage on pair of basic residue | Copper | Disease mutation | Drug binding | Ga module | Glycation | Glycoprotein | Human serum albumin | Lipid-binding | Metal-binding | Naproxen | Peptidoglycan-anchor | Polymorphism | Protein binding | Secreted | Three-helix bundle
