Interleukin

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* '''IL-8''' induces chemotaxis and phagocytosis.<br />
* '''IL-8''' induces chemotaxis and phagocytosis.<br />
* '''IL-10''' see [[Interleukin-10]].<br />
* '''IL-10''' see [[Interleukin-10]].<br />
-
*''' IL-12''' induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br />
+
* '''IL-11''' involved in the stimulation of megakaryocyte maturation.<br />
 +
* ''' IL-12''' induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br />
* '''IL-13''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br />
* '''IL-13''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br />
* '''IL-15''' see [[Interleukin-15]].<br />
* '''IL-15''' see [[Interleukin-15]].<br />
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* '''IL-18''' induces cell-mediated immunity following infection by microbial lipopolysaccharides.<br />
* '''IL-18''' induces cell-mediated immunity following infection by microbial lipopolysaccharides.<br />
* '''IL-19''' induces activation of the signal transducer and activator of STAT3.<br />
* '''IL-19''' induces activation of the signal transducer and activator of STAT3.<br />
-
*''' IL-21''' has potent effect on natural killer cells.<br />
+
* ''' IL-21''' has potent effect on natural killer cells.<br />
* '''IL-22''' stimulates inflammatory responses like S100 and defensin.<br />
* '''IL-22''' stimulates inflammatory responses like S100 and defensin.<br />
-
*''' IL-23''' induces activation of the signal transducer and activator of STAT4.<br />
+
* ''' IL-23''' induces activation of the signal transducer and activator of STAT4.<br />
* '''IL-28''' has a role in the immune defense against viruses.<br />
* '''IL-28''' has a role in the immune defense against viruses.<br />
* '''IL-29''' similar to IL-28.<br />
* '''IL-29''' similar to IL-28.<br />
* '''IL-33''' induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.<br />
* '''IL-33''' induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.<br />
* '''IL-34''' increases growth or survival of monocytes.<br />
* '''IL-34''' increases growth or survival of monocytes.<br />
-
+
* '''IL-36''' acts on naïve CD4+ T cells.
 +
 
==3D structures of interleukin==
==3D structures of interleukin==
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**[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor<BR />
**[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor<BR />
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
 +
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
*IL-3
*IL-3
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**[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR />
**[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR />
**[[3qb7]] - hIL-4 + cytokine receptor common γ<BR />
**[[3qb7]] - hIL-4 + cytokine receptor common γ<BR />
 +
**[[4ydy]] – hIL-4 + darpin<BR />
**[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α
**[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α
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**[[4j4l]] – hIL-6 + internalin B<BR />
**[[4j4l]] – hIL-6 + internalin B<BR />
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
 +
**[[4cni]], [[4o9h]] – hIL-6 + antibody<BR />
*IL-7
*IL-7
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**[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10<BR />
**[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10<BR />
 +
**[[4x51]] – mIL-10<BR />
**[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR />
**[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR />
**[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α
**[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α
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**[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR />
**[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR />
**[[1lk3]] - hvIL-10 residues 26-175 + antibody
**[[1lk3]] - hvIL-10 residues 26-175 + antibody
 +
 +
*IL-11
 +
 +
**[[4mhl]] - hIL-11<br />
*IL-12
*IL-12
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**[[1f42]] - hIL-12 β P40 domain<BR />
**[[1f42]] - hIL-12 β P40 domain<BR />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
 +
**[[4oe8]], [[4og9]] - hIL-12 β + hIL-23 α + alphabody MB3<br />
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin
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*IL-18 (Interferon-γ inducing factor)
*IL-18 (Interferon-γ inducing factor)
 +
**[[3wo2]] – hIL-18 <BR />
**[[1j0s]] – hIL-18 - NMR<BR />
**[[1j0s]] – hIL-18 - NMR<BR />
**[[4hjj]] - hIL-18 + antibody<br />
**[[4hjj]] - hIL-18 + antibody<br />
**[[2vxt]] - hIL-18 (mutant) + antibody<BR />
**[[2vxt]] - hIL-18 (mutant) + antibody<BR />
**[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein<br />
**[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein<br />
-
**[[4eee]], [[4ekx]] - hIL-18 (mutant) + 14L protein
+
**[[4eee]], [[4ekx]] - hIL-18 (mutant) + 14L protein<br />
 +
**[[3wo3]], [[4r6u]] - hIL-18 + IL-18 receptor<br />
 +
**[[3wo4]] - hIL-18 + IL-18 receptor + IL-18 receptor accessory protein<br />
*IL-19
*IL-19
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**[[1ykb]], [[1m4r]] – hIL-22<BR />
**[[1ykb]], [[1m4r]] – hIL-22<BR />
 +
**[[4ok6]] – IL-22 – zebra fish<BR />
**[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2<BR />
**[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2<BR />
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
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**[[4exp]] - mIL-34 active core + macrophage colony-stimulating factor 1 receptor<br />
**[[4exp]] - mIL-34 active core + macrophage colony-stimulating factor 1 receptor<br />
**[[4dke]], [[4dkf]] - hIL-34 active core + antibody
**[[4dke]], [[4dkf]] - hIL-34 active core + antibody
 +
 +
*IL-36
 +
 +
**[[4ize]] - hIL-36 γ<br />
 +
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 08:19, 28 April 2015

Template:STRUCTURE 2nvh

Interleukin (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.

  • IL-1 is a group of 11 cytokines which regulate immune and inflammatory response. See Interleukin-1 beta.
  • IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.
  • IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.
  • IL-4 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  • IL-5 stimulates B cell growth and increases immunoglobulin secretion.
  • IL-6 is both a pro-inflammatory cytokine and anti-inflammatory myokine.
  • IL-7 is a cytokine important for B and T cells development.
  • IL-8 induces chemotaxis and phagocytosis.
  • IL-10 see Interleukin-10.
  • IL-11 involved in the stimulation of megakaryocyte maturation.
  • IL-12 induces the differentiation of naive helper T cells (Th0) to Th1 cells.
  • IL-13 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  • IL-15 see Interleukin-15.
  • IL-16 acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.
  • IL-17 recruits monocytes and neutrophils to the site of inflammation.
  • IL-18 induces cell-mediated immunity following infection by microbial lipopolysaccharides.
  • IL-19 induces activation of the signal transducer and activator of STAT3.
  • IL-21 has potent effect on natural killer cells.
  • IL-22 stimulates inflammatory responses like S100 and defensin.
  • IL-23 induces activation of the signal transducer and activator of STAT4.
  • IL-28 has a role in the immune defense against viruses.
  • IL-29 similar to IL-28.
  • IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.
  • IL-34 increases growth or survival of monocytes.
  • IL-36 acts on naïve CD4+ T cells.

3D structures of interleukin

Updated on 28-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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