2viu
From Proteopedia
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|PDB= 2viu |SIZE=350|CAPTION= <scene name='initialview01'>2viu</scene>, resolution 2.5Å | |PDB= 2viu |SIZE=350|CAPTION= <scene name='initialview01'>2viu</scene>, resolution 2.5Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | + | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2viu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2viu OCA], [http://www.ebi.ac.uk/pdbsum/2viu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2viu RCSB]</span> | ||
}} | }} | ||
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[[Category: Skehel, J J.]] | [[Category: Skehel, J J.]] | ||
[[Category: Wharton, S A.]] | [[Category: Wharton, S A.]] | ||
| - | [[Category: NAG]] | ||
[[Category: envelope protein]] | [[Category: envelope protein]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
[[Category: hemagglutinin]] | [[Category: hemagglutinin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:12:50 2008'' |
Revision as of 02:12, 31 March 2008
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| , resolution 2.5Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
INFLUENZA VIRUS HEMAGGLUTININ
Overview
The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.
About this Structure
2VIU is a Single protein structure of sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.
Reference
Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077
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