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3j9x
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| - | ''' | + | ==A Virus that Infects a Hyperthermophile Encapsidates A-Form DNA== |
| + | <StructureSection load='3j9x' size='340' side='right' caption='[[3j9x]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3j9x]] is a 60 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_islandicus_rod-shaped_virus_2 Sulfolobus islandicus rod-shaped virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J9X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J9X FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j9x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j9x RCSB], [http://www.ebi.ac.uk/pdbsum/3j9x PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Extremophiles, microorganisms thriving in extreme environmental conditions, must have proteins and nucleic acids that are stable at extremes of temperature and pH. The nonenveloped, rod-shaped virus SIRV2 (Sulfolobus islandicus rod-shaped virus 2) infects the hyperthermophilic acidophile Sulfolobus islandicus, which lives at 80 degrees C and pH 3. We have used cryo-electron microscopy to generate a three-dimensional reconstruction of the SIRV2 virion at ~4 angstrom resolution, which revealed a previously unknown form of virion organization. Although almost half of the capsid protein is unstructured in solution, this unstructured region folds in the virion into a single extended alpha helix that wraps around the DNA. The DNA is entirely in the A-form, which suggests a common mechanism with bacterial spores for protecting DNA in the most adverse environments. | ||
| - | + | Virology. A virus that infects a hyperthermophile encapsidates A-form DNA.,DiMaio F, Yu X, Rensen E, Krupovic M, Prangishvili D, Egelman EH Science. 2015 May 22;348(6237):914-7. doi: 10.1126/science.aaa4181. PMID:25999507<ref>PMID:25999507</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Sulfolobus islandicus rod-shaped virus 2]] | ||
| + | [[Category: DiMaio, F]] | ||
[[Category: Egelman, E]] | [[Category: Egelman, E]] | ||
| + | [[Category: Krupovic, M]] | ||
| + | [[Category: Prangishvili, D]] | ||
| + | [[Category: Rensen, E]] | ||
[[Category: Yu, X]] | [[Category: Yu, X]] | ||
| - | [[Category: | + | [[Category: Archaeal virus]] |
| - | [[Category: | + | [[Category: Helical symmetry]] |
| - | [[Category: | + | [[Category: Virus]] |
| - | + | ||
Revision as of 12:36, 3 June 2015
A Virus that Infects a Hyperthermophile Encapsidates A-Form DNA
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