2vl5
From Proteopedia
(New page: 200px {{Structure |PDB= 2vl5 |SIZE=350|CAPTION= <scene name='initialview01'>2vl5</scene>, resolution 2.10Å |SITE= |LIGAND= |ACTIVITY= |GENE= }} '''STRU...) |
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl5 OCA], [http://www.ebi.ac.uk/pdbsum/2vl5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vl5 RCSB]</span> | ||
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[[Category: rheumatoid factor]] | [[Category: rheumatoid factor]] | ||
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Revision as of 02:13, 31 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF ANTI-COLLAGEN TYPE II FAB CIIC1
Overview
Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic autoantibody, which induces arthritis in mice. We crystallized and solved the structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction between the CDR regions of one Fab to the CH1 domain of another Fab, which resembles an antibody-antigen interaction. ELISA experiments confirmed the cross-reactivity of both the full CIIC1 antibody and a single chain Fv fragment to other anti-collagen antibodies which are of different isotypes and epitope specificity. The rheumatoid factor like reactivity of CIIC1 antibody together with its collagen type II specificity may explain the pathogenicity of this antibody.
About this Structure
2VL5 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: Structure to function analysis., Uysal H, Sehnert B, Nandakumar KS, Boiers U, Burkhardt H, Holmdahl R, Thunnissen MM, Mol Immunol. 2008 Apr;45(8):2196-204. Epub 2008 Feb 1. PMID:18241923
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