This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2vlj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 7: Line 7:
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=[[1uqs|1UQS]], [[1bd2|1BD2]], [[2ak4|2AK4]], [[1ypz|1YPZ]], [[1im3|1IM3]], [[1uxw|1UXW]], [[1i7u|1I7U]], [[1c16|1C16]], [[1hsa|1HSA]], [[2axf|2AXF]], [[1gzp|1GZP]], [[2bnq|2BNQ]], [[1w72|1W72]], [[2jcc|2JCC]], [[2bck|2BCK]], [[1de4|1DE4]], [[1n2r|1N2R]], [[1exu|1EXU]], [[1qrn|1QRN]], [[2hla|2HLA]], [[1mhe|1MHE]], [[1im9|1IM9]], [[1eez|1EEZ]], [[1jht|1JHT]], [[1qqd|1QQD]], [[1qr1|1QR1]], [[1zs8|1ZS8]], [[1hla|1HLA]], [[1jgd|1JGD]], [[1i1y|1I1Y]], [[1vgk|1VGK]], [[1age|1AGE]], [[1ur7|1UR7]], [[1s9x|1S9X]], [[1hhg|1HHG]], [[1a9e|1A9E]], [[1duz|1DUZ]], [[2clr|2CLR]], [[3hla|3HLA]], [[1m05|1M05]], [[1tvb|1TVB]], [[2v2w|2V2W]], [[1onq|1ONQ]], [[1a1n|1A1N]], [[1lp9|1LP9]], [[1zsd|1ZSD]], [[1m6o|1M6O]], [[2bsu|2BSU]], [[1hhk|1HHK]], [[1zt4|1ZT4]], [[1hsb|1HSB]], [[1x7q|1X7Q]], [[1ce6|1CE6]], [[1py4|1PY4]], [[1syv|1SYV]], [[2j8u|2J8U]], [[1sys|1SYS]], [[1ogt|1OGT]], [[1cg9|1CG9]], [[1p7q|1P7Q]], [[1q94|1Q94]], [[1jnj|1JNJ]], [[1agb|1AGB]], [[2d31|2D31]], [[1aqd|1AQD]], [[1xz0|1XZ0]], [[1lds|1LDS]], [[1hhh|1HHH]], [[1tvh|1TVH]], [[1xr8|1XR8]], [[2bss|2BSS]], [[1a1m|1A1M]], [[1e28|1E28]], [[2v2x|2V2X]], [[1xr9|1XR9]], [[2gj6|2GJ6]], [[1efx|1EFX]], [[1qlf|1QLF]], [[2av1|2AV1]], [[1tmc|1TMC]], [[1qsf|1QSF]], [[1duy|1DUY]], [[1jge|1JGE]], [[1kpr|1KPR]], [[2hjl|2HJL]], [[1qew|1QEW]], [[1w0v|1W0V]], [[1k5n|1K5N]], [[1ao7|1AO7]], [[2bnr|2BNR]], [[1xh3|1XH3]], [[2bst|2BST]], [[1mi5|1MI5]], [[2h26|2H26]], [[1s9y|1S9Y]], [[1a1o|1A1O]], [[1agf|1AGF]], [[2a83|2A83]], [[1oga|1OGA]], [[2f8o|2F8O]], [[2bsv|2BSV]], [[2cii|2CII]], [[1i7r|1I7R]], [[1jf1|1JF1]], [[2c7u|2C7U]], [[2f74|2F74]], [[1e27|1E27]], [[1w0w|1W0W]], [[1gzq|1GZQ]], [[1uxs|1UXS]], [[1akj|1AKJ]], [[2hjk|2HJK]], [[2vb5|2VB5]], [[1agd|1AGD]], [[1r3h|1R3H]], [[1eey|1EEY]], [[1i7t|1I7T]], [[1i4f|1I4F]], [[1ydp|1YDP]], [[2bsr|2BSR]], [[1b0g|1B0G]], [[1b0r|1B0R]], [[1of2|1OF2]], [[1hhi|1HHI]], [[1qse|1QSE]], [[1a9b|1A9B]], [[2axg|2AXG]], [[2bvq|2BVQ]], [[1agc|1AGC]], [[1hhj|1HHJ]], [[1qvo|1QVO]], [[1s9w|1S9W]], [[1ktl|1KTL]], [[1a6z|1A6Z]], [[2cik|2CIK]], [[2uwe|2UWE]], [[1i1f|1I1F]], [[2av7|2AV7]], [[2vll|2VLL]], [[2vlm|2VLM]], [[2vlk|2VLK]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vlj OCA], [http://www.ebi.ac.uk/pdbsum/2vlj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vlj RCSB]</span>
}}
}}
Line 51: Line 54:
[[Category: ubl conjugation]]
[[Category: ubl conjugation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:47:33 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:13:30 2008''

Revision as of 02:13, 31 March 2008

Image:2vlj.jpg


PDB ID 2vlj

Drag the structure with the mouse to rotate
, resolution 2.40Å
Related: 1UQS, 1BD2, 2AK4, 1YPZ, 1IM3, 1UXW, 1I7U, 1C16, 1HSA, 2AXF, 1GZP, 2BNQ, 1W72, 2JCC, 2BCK, 1DE4, 1N2R, 1EXU, 1QRN, 2HLA, 1MHE, 1IM9, 1EEZ, 1JHT, 1QQD, 1QR1, 1ZS8, 1HLA, 1JGD, 1I1Y, 1VGK, 1AGE, 1UR7, 1S9X, 1HHG, 1A9E, 1DUZ, 2CLR, 3HLA, 1M05, 1TVB, 2V2W, 1ONQ, 1A1N, 1LP9, 1ZSD, 1M6O, 2BSU, 1HHK, 1ZT4, 1HSB, 1X7Q, 1CE6, 1PY4, 1SYV, 2J8U, 1SYS, 1OGT, 1CG9, 1P7Q, 1Q94, 1JNJ, 1AGB, 2D31, 1AQD, 1XZ0, 1LDS, 1HHH, 1TVH, 1XR8, 2BSS, 1A1M, 1E28, 2V2X, 1XR9, 2GJ6, 1EFX, 1QLF, 2AV1, 1TMC, 1QSF, 1DUY, 1JGE, 1KPR, 2HJL, 1QEW, 1W0V, 1K5N, 1AO7, 2BNR, 1XH3, 2BST, 1MI5, 2H26, 1S9Y, 1A1O, 1AGF, 2A83, 1OGA, 2F8O, 2BSV, 2CII, 1I7R, 1JF1, 2C7U, 2F74, 1E27, 1W0W, 1GZQ, 1UXS, 1AKJ, 2HJK, 2VB5, 1AGD, 1R3H, 1EEY, 1I7T, 1I4F, 1YDP, 2BSR, 1B0G, 1B0R, 1OF2, 1HHI, 1QSE, 1A9B, 2AXG, 2BVQ, 1AGC, 1HHJ, 1QVO, 1S9W, 1KTL, 1A6Z, 2CIK, 2UWE, 1I1F, 2AV7, 2VLL, 2VLM, 2VLK


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN


Overview

Immunodominant and public T cell receptor (TCR) usage is relatively common in many viral diseases yet surprising in the context of the large naive TCR repertoire. We examined the highly conserved Vbeta17:Valpha10.2 JM22 T cell response to the influenza matrix peptide (58-66)-HLA-A( *)0201 (HLA-A2-flu) through extensive kinetic, thermodynamic, and structural analyses. We found several conformational adjustments that accompany JM22-HLA-A2-flu binding and identified a binding "hotspot" within the Vbeta domain of the TCR. Within this hotspot, key germline-encoded CDR1 and CDR2 loop residues and a crucial but commonly coded residue in the hypervariable region of CDR3 provide the basis for the substantial bias in the selection of the germline-encoded Vbeta17 domain. The chances of having a substantial number of T cells in the naive repertoire that have HLA-A2-flu-specific Vbeta17 receptors may consequently be relatively high, thus explaining the immunodominant usage of this clonotype.

About this Structure

2VLJ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain., Ishizuka J, Stewart-Jones GB, van der Merwe A, Bell JI, McMichael AJ, Jones EY, Immunity. 2008 Feb;28(2):171-82. PMID:18275829

Page seeded by OCA on Mon Mar 31 05:13:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vlj"
Personal tools