4zfx
From Proteopedia
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| - | ''' | + | ==Siderocalin-mediated recognition and cellular uptake of actinides== |
| - | + | <StructureSection load='4zfx' size='340' side='right' caption='[[4zfx]], [[Resolution|resolution]] 2.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zfx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH:THORIUM+ION'>TH</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zfx RCSB], [http://www.ebi.ac.uk/pdbsum/4zfx PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: An, D | + | [[http://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN]] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Strong, R | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Abergel, R J]] | ||
| + | [[Category: Allred, B E]] | ||
| + | [[Category: An, D D]] | ||
| + | [[Category: Gauny, S S]] | ||
| + | [[Category: Ralston, C Y]] | ||
| + | [[Category: Rupert, P B]] | ||
| + | [[Category: Strong, R K]] | ||
[[Category: Sturzbecher-Hoehne, M]] | [[Category: Sturzbecher-Hoehne, M]] | ||
| - | [[Category: | + | [[Category: Metal binding protein-inhibitor complex]] |
| - | + | ||
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Revision as of 20:16, 5 August 2015
Siderocalin-mediated recognition and cellular uptake of actinides
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