Leukotriene A4 Hydrolase
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_2xpz| PDB=2xpz | SIZE=400| SCENE= |right|CAPTION=Leukotriene A4 Hydrolase complex with butanediol and PEG [[2xpz]] }} | ||
| - | [[Leukotriene A4 Hydrolase]] (LTA4H) is an aminopeptidase which converts leukotriene A4 to leukotriene B4 as part of the arachidonic acid metabolism. | + | <StructureSection load='1hs6' size='350' side='right' caption='Leukotriene A4 Hydrolase complex with (PDB entry [[2pm4]])' scene=''> |
| + | == Function == | ||
| + | [[Leukotriene A4 Hydrolase]] (LTA4H) is an aminopeptidase which converts leukotriene A4 to leukotriene B4 as part of the arachidonic acid metabolism<ref>PMID:24771855</ref> . | ||
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| + | == Relevance == | ||
| + | LTA4H inhibitors have potential in targeting chronic, autoimmune-driven inflammation<ref>PMID:19876785</ref> . | ||
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| + | == Disease == | ||
| + | Mutations in LTA4H are linked to susceptibility to asthma and to cardiovascular disease. | ||
== 3D Structures of Leukotriene A4 Hydrolase == | == 3D Structures of Leukotriene A4 Hydrolase == | ||
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| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:40, 11 April 2016
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