This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Macrophage inhibitory factor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
<StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene=''>
<StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene=''>
 +
== Function ==
 +
'''Macrophage inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>. MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60.
-
'''Macrophage inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens. MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60.
+
== Relevance ==
 +
MIF plays a role in various solid and hematologic tumors<ref>PMID:19326434</ref>. MIF is overexpressed in various tumors and is suggested to be the molecular link between chronic inflammation and cancer. MIF has a role in skin inflammation, immune response, disease, tumorigenesis and wound healing<ref>PMID:15659324</ref>. MIF has a role in Alzheimer disease and its inhibition may prevent the disease onset<ref>PMID:20200619</ref>.
</StructureSection>
</StructureSection>
Line 35: Line 38:
**[[4p7m]], [[4p7s]] – MIF + inhibitor – ''Plasmodium falciparum''<BR />
**[[4p7m]], [[4p7s]] – MIF + inhibitor – ''Plasmodium falciparum''<BR />
}}
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:31, 14 April 2016

Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry 2ooh)

Drag the structure with the mouse to rotate

3D structures of macrophage inhibitory factor

Updated on 14-April-2016

References

  1. ↑ Nishihira J. Macrophage migration inhibitory factor (MIF): its essential role in the immune system and cell growth. J Interferon Cytokine Res. 2000 Sep;20(9):751-62. PMID:11032394 doi:http://dx.doi.org/10.1089/10799900050151012
  2. ↑ Bach JP, Deuster O, Balzer-Geldsetzer M, Meyer B, Dodel R, Bacher M. The role of macrophage inhibitory factor in tumorigenesis and central nervous system tumors. Cancer. 2009 May 15;115(10):2031-40. doi: 10.1002/cncr.24245. PMID:19326434 doi:http://dx.doi.org/10.1002/cncr.24245
  3. ↑ Shimizu T. Role of macrophage migration inhibitory factor (MIF) in the skin. J Dermatol Sci. 2005 Feb;37(2):65-73. PMID:15659324 doi:http://dx.doi.org/10.1016/j.jdermsci.2004.08.007
  4. ↑ Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, Popp J, Noelker C, Reese JP, Al-Abed Y, Dodel R. The role of macrophage migration inhibitory factor in Alzheimer's disease. Mol Med. 2010 Mar;16(3-4):116-21. doi: 10.2119/molmed.2009.00123. Epub 2010 Feb, 28. PMID:20200619 doi:http://dx.doi.org/10.2119/molmed.2009.00123

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Macrophage_inhibitory_factor"
Personal tools