Methanol dehydrogenase

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{{STRUCTURE_2ad6| PDB=2ad6 | SIZE=400| SCENE= |right| CAPTION=Methanol dehydrogenase large subunit (grey and pink) and small subunit (green and yellow) complex with cofactor PQQ and Ca+2 ion (green), [[2ad6]] }}
{{STRUCTURE_2ad6| PDB=2ad6 | SIZE=400| SCENE= |right| CAPTION=Methanol dehydrogenase large subunit (grey and pink) and small subunit (green and yellow) complex with cofactor PQQ and Ca+2 ion (green), [[2ad6]] }}
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== Function ==
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'''Methanol dehydrogenase''' (MDH) is a quinoprotein which catalyzes the conversion of methanol and NAD+ or NADP+ to formaldeyde and NADH or NADPH and H+. MDH is a pyrroloquinoline quinone (PQQ)-dependent enzyme. MDH requires a divalent cation like Ca+2 for catalytic activity<ref>PMID:12686102</ref>.
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== Structural highlights ==
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PQQ and Ca+2 are bound in a funnel-shaped internal cavity of MDH<ref>PMID:21356200</ref>.
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'''Methanol dehydrogenase''' (MDH) is a quinoprotein which catalyzes the conversion of methanol and NAD+ or NADP+ to formaldeyde and NADH or NADPH and H+. MDH is a pyrroloquinoline quinone (PQQ) -dependent enzyme. MDH requires a divalent cation like Ca+2 for catalytic activity.
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==3D structures of methanol dehydrogenase==
==3D structures of methanol dehydrogenase==
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[[4mae]] - MDH + Ce + PQQ – ''Methylacidiphilum fumariolicum''<br />
[[4mae]] - MDH + Ce + PQQ – ''Methylacidiphilum fumariolicum''<br />
[[4tqo]] - MDH + Ca + PQQ – ''Methylococcus capsulatus''<br />
[[4tqo]] - MDH + Ca + PQQ – ''Methylococcus capsulatus''<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:14, 21 April 2016

Template:STRUCTURE 2ad6

Contents

Function

Methanol dehydrogenase (MDH) is a quinoprotein which catalyzes the conversion of methanol and NAD+ or NADP+ to formaldeyde and NADH or NADPH and H+. MDH is a pyrroloquinoline quinone (PQQ)-dependent enzyme. MDH requires a divalent cation like Ca+2 for catalytic activity[1].

Structural highlights

PQQ and Ca+2 are bound in a funnel-shaped internal cavity of MDH[2].

3D structures of methanol dehydrogenase

Updated on 21-April-2016

4aah, 1g72, 2ad6, 2ad7, 2ad8 – MmMDH α+β + Ca + PQQ – Methylophilus methylotrophus
1h4i, 1w6s - MeMDH α+β + Ca + PQQ – Methylobacterium extorquens
1h4j - MeMDH α (mutant) +β + Ca + PQQ
1lrw - MDH α+β + Ca + PQQ – Paracoccus denitrificans
2d0v - MDH α+β + Ca + PQQ – Hyphomicrobium denitrificans
4mae - MDH + Ce + PQQ – Methylacidiphilum fumariolicum
4tqo - MDH + Ca + PQQ – Methylococcus capsulatus

References

  1. ↑ Anthony C, Williams P. The structure and mechanism of methanol dehydrogenase. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):18-23. PMID:12686102
  2. ↑ Li J, Gan JH, Mathews FS, Xia ZX. The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase. Biochem Biophys Res Commun. 2011 Mar 25;406(4):621-6. Epub 2011 Feb 26. PMID:21356200 doi:10.1016/j.bbrc.2011.02.107

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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