2n26
From Proteopedia
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| - | ''' | + | ==Solution structure of Miz-1 zinc fingers 3 and 4== |
| - | + | <StructureSection load='2n26' size='340' side='right' caption='[[2n26]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n26]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N26 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n25|2n25]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2n26 RCSB], [http://www.ebi.ac.uk/pdbsum/2n26 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ZBT17_HUMAN ZBT17_HUMAN]] Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation.<ref>PMID:9312026</ref> <ref>PMID:9308237</ref> <ref>PMID:19164764</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bedard, M]] | [[Category: Bedard, M]] | ||
[[Category: Lavigne, P]] | [[Category: Lavigne, P]] | ||
| + | [[Category: C2h2 zinc finger]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Miz-1]] | ||
| + | [[Category: Zbtb17]] | ||
Revision as of 15:19, 17 June 2015
Solution structure of Miz-1 zinc fingers 3 and 4
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