4zd5
From Proteopedia
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| - | ''' | + | ==Catalytic domain of Sst2 F403A mutant== |
| - | + | <StructureSection load='4zd5' size='340' side='right' caption='[[4zd5]], [[Resolution|resolution]] 2.07Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zd5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZD5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jxe|4jxe]], [[4ms7|4ms7]], [[4msj|4msj]], [[3rzu|3rzu]], [[2znr|2znr]], [[4zd4|4zd4]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zd5 OCA], [http://pdbe.org/4zd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zd5 RCSB], [http://www.ebi.ac.uk/pdbsum/4zd5 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Shrestha, R | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/SST2_SCHPO SST2_SCHPO]] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.<ref>PMID:17660439</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Shrestha, R K]] | ||
| + | [[Category: Helix-beta-helix sandwich zinc metalloprotease endosome ubiquitin]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 04:05, 16 October 2015
Catalytic domain of Sst2 F403A mutant
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