4zi1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==HUMAN ESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH KB095285 AND CIA12 COACTIVATOR PEPTIDE== | |
| - | + | <StructureSection load='4zi1' size='340' side='right' caption='[[4zi1]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zi1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZI1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KB0:2-(4-HYDROXYPHENYL)-7-METHYL-3-PHENYL-1H-INDEN-5-OL'>KB0</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zi1 OCA], [http://pdbe.org/4zi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zi1 RCSB], [http://www.ebi.ac.uk/pdbsum/4zi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zi1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. [[http://www.uniprot.org/uniprot/NCOA5_HUMAN NCOA5_HUMAN]] Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).<ref>PMID:15073177</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bonn, T]] | ||
[[Category: Kauppi, B]] | [[Category: Kauppi, B]] | ||
| - | [[Category: | + | [[Category: Beta selective]] |
| + | [[Category: Erb]] | ||
| + | [[Category: Estrogen receptor beta]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 10:14, 13 July 2016
HUMAN ESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH KB095285 AND CIA12 COACTIVATOR PEPTIDE
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