This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Pantothenate synthetase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_2a7x| PDB=2a7x | SIZE=400| SCENE= |right|CAPTION=Pantothenate synthetase complex with AMP (stick model), sulfate and glycerol [[2a7x]] }} | ||
| - | '''Pantothenate synthetase''' (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate. Pantothenate (vitamin B5) biosynthesis is essential for the virulence of Mycobacterium tuberculosis thus its blockage can be used as a potential drug target. | + | <StructureSection load='3uy4' size='350' side='right' caption='Pantothenate synthetase complex with AMP (stick model), sulfate and glycerol (PDB entry [[3uy4]])' scene=''> |
| + | == Function == | ||
| + | '''Pantothenate synthetase''' (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate. | ||
| + | |||
| + | == Relevance == | ||
| + | Pantothenate (vitamin B5) biosynthesis is essential for the virulence of ''Mycobacterium tuberculosis'' thus its blockage can be used as a potential drug target. | ||
==3D structures of pantothenate synthetase== | ==3D structures of pantothenate synthetase== | ||
| Line 52: | Line 56: | ||
**[[1n2b]], [[1n2e]] – MtPS + pantoate + AMPCPP | **[[1n2b]], [[1n2e]] – MtPS + pantoate + AMPCPP | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:22, 14 June 2016
| |||||||||||
