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Peroxiredoxin
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_1qq2| PDB=1qq2 | SIZE=400| SCENE= |right|CAPTION=Peroxiredoxin dimer complex with Cl- ions [[1qq2]]}} | {{STRUCTURE_1qq2| PDB=1qq2 | SIZE=400| SCENE= |right|CAPTION=Peroxiredoxin dimer complex with Cl- ions [[1qq2]]}} | ||
| - | + | == Function == | |
[[Peroxiredoxin]] (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue. | [[Peroxiredoxin]] (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue. | ||
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| + | == Relevance == | ||
| + | Prx are over expressed in cancer tissue<ref>PMID:11497302</ref>. | ||
== 3D Structures of Peroxiredoxin == | == 3D Structures of Peroxiredoxin == | ||
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| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:15, 21 June 2016
Contents |
Function
Peroxiredoxin (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue.
Relevance
Prx are over expressed in cancer tissue[1].
3D Structures of Peroxiredoxin
Updated on 21-June-2016
References
- ↑ Noh DY, Ahn SJ, Lee RA, Kim SW, Park IA, Chae HZ. Overexpression of peroxiredoxin in human breast cancer. Anticancer Res. 2001 May-Jun;21(3B):2085-90. PMID:11497302
