Phosphoribosyltransferase

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{{STRUCTURE_3l0k| PDB=3l0k | SIZE=400| SCENE= |right|CAPTION=Human orotate phosphoribosyltransferase dimer complex with UMP derivative (stick model) and glycerol [[3l0k]].}}
{{STRUCTURE_3l0k| PDB=3l0k | SIZE=400| SCENE= |right|CAPTION=Human orotate phosphoribosyltransferase dimer complex with UMP derivative (stick model) and glycerol [[3l0k]].}}
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== Function ==
'''Phosphoribosyltransferase''' (PRT) are transferases which belong to several classes: <br />
'''Phosphoribosyltransferase''' (PRT) are transferases which belong to several classes: <br />
-
1. '''Hypoxanthine-guanine PRT''' (HGPRT). HGPRT is part of the purine biosynthesis and catalyzes the formation of GMP from guanine, xanthosine monophosphate from xanthosine and of inosine monophosphate from hypoxanthine. <br />
+
1. '''Hypoxanthine-guanine PRT''' (HPRT). HPRT is part of the purine biosynthesis and catalyzes the formation of GMP from guanine, xanthosine monophosphate from xanthosine and of inosine monophosphate from hypoxanthine. <br />
2. '''Orotate PRT''' (OPRT). OPRT is part of the pyrimidine biosynthesis and catalyzes the formation of orotidine 5’-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate (PRPP). <br />
2. '''Orotate PRT''' (OPRT). OPRT is part of the pyrimidine biosynthesis and catalyzes the formation of orotidine 5’-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate (PRPP). <br />
3. '''Quinolinic acid PRT''' (QAPRT ). QAPRT is a degrading enzyme found in the brain. <br />
3. '''Quinolinic acid PRT''' (QAPRT ). QAPRT is a degrading enzyme found in the brain. <br />
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8. '''Nicotinate PRT''' (NIPRT). NIPRT catalyzes the formation of nicotinate from nicotinate ribonucleotide and diphosphate. <br />
8. '''Nicotinate PRT''' (NIPRT). NIPRT catalyzes the formation of nicotinate from nicotinate ribonucleotide and diphosphate. <br />
9. '''Nicotinamide PRT''' (NMPRT). NMPRT catalyzes the formation of nicotinamide from nicotinamide ribonucleotide (NMN) and diphosphate.
9. '''Nicotinamide PRT''' (NMPRT). NMPRT catalyzes the formation of nicotinamide from nicotinamide ribonucleotide (NMN) and diphosphate.
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== Disease ==
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</StructureSection>
</StructureSection>
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*'''Hypoxanthine-guanine phosphoribosyltransferase'''
*'''Hypoxanthine-guanine phosphoribosyltransferase'''
-
**[[1nul]], [[1grv]] - EcHGPRT <br />
+
**[[1nul]], [[1grv]] - EcHPRT <br />
-
**[[1dbr]] - TgHGPRT – ''Toxoplasma gondii''<br />
+
**[[1dbr]] - TgHPRT – ''Toxoplasma gondii''<br />
-
**[[1tc1]] - TcHGPRT – ''Trypanosoma cruzi''<br />
+
**[[1tc1]] - TcHPRT – ''Trypanosoma cruzi''<br />
-
**[[1r3u]] - TteHGPRT – ''Thermoanaerobacter tengongensis''<br />
+
**[[1r3u]] - TteHPRT – ''Thermoanaerobacter tengongensis''<br />
-
**[[2geb]] - TteHGPRT (mutant) <br />
+
**[[2geb]] - TteHPRT (mutant) <br />
-
**[[1vdm]] - PhHGPRT – ''Pyrococcus horikoshii''<br />
+
**[[1vdm]] - PhHPRT – ''Pyrococcus horikoshii''<br />
-
**[[1z7g]] - hHGPRT <br />
+
**[[1z7g]] - hHPRT <br />
-
**[[3h83]], [[3hvu]], [[3o7m]], [[4qyi]] - BaHGPRT<br />
+
**[[3h83]], [[3hvu]], [[3o7m]], [[4qyi]] - BaHPRT<br />
-
**[[3acb]] - TtHGPRT – ''Thermus thermophilus''<br />
+
**[[3acb]] - TtHPRT – ''Thermus thermophilus''<br />
-
**[[3ohp]] - VcHGPRT <br />
+
**[[3ohp]] - VcHPRT <br />
-
**[[4lyy]] – HGPRT – ''Shewanella pealeana''<br />
+
**[[4lyy]] – HPRT – ''Shewanella pealeana''<br />
-
**[[4pfq]] – HGPRT – ''Brachybacterium faecium''<br />
+
**[[4pfq]] – HPRT – ''Brachybacterium faecium''<br />
-
**[[4qri]] – HGPRT – ''Leptospira interrogans''<br />
+
**[[4qri]] – HPRT – ''Leptospira interrogans''<br />
-
**[[4rqa]], [[4rqb]] – HGPRT – ''Staphylococcus aureus''<br />
+
**[[4rqa]], [[4rqb]] – HPRT – ''Staphylococcus aureus''<br />
*Hypoxanthine-guanine phosphoribosyltransferase binary complex
*Hypoxanthine-guanine phosphoribosyltransferase binary complex
-
**[[1a98]], [[1a97]] - EcHGPRT (mutant) + GMP<br />
+
**[[1a98]], [[1a97]] - EcHPRT (mutant) + GMP<br />
-
**[[1g9s]] - EcHGPRT + IMP<BR />
+
**[[1g9s]] - EcHPRT + IMP<BR />
-
**[[1g9t]] - EcHGPRT + GMP<br />
+
**[[1g9t]] - EcHPRT + GMP<br />
-
**[[1hmp]], [[2vfa]] - hHGPRT + GMP<br />
+
**[[1hmp]], [[2vfa]] - hHPRT + GMP<br />
-
**[[3gep]], [[3ggj]], [[4jit]], [[4jls]] - hHGPRT + guanine derivative<br />
+
**[[3gep]], [[3ggj]], [[4jit]], [[4jls]] - hHPRT + guanine derivative<br />
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**[[3ggc]] - hHGPRT + hypoxanthine derivative<br />
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**[[3ggc]] - hHPRT + hypoxanthine derivative<br />
-
**[[4ijq]], [[4rab]], [[4rac]], [[4rad]], [[4ran]], [[4rao]], [[4raq]] - hHGPRT + inhibitor<br />
+
**[[4ijq]], [[4rab]], [[4rac]], [[4rad]], [[4ran]], [[4rao]], [[4raq]] - hHPRT + inhibitor<br />
-
**[[4kn6]] - hHGPRT + antiviral agent<br />
+
**[[4kn6]] - hHPRT + antiviral agent<br />
-
**[[1hgx]] - HGPRT + GMP – ''Tritrichomonas foetus''<br />
+
**[[1hgx]] - HPRT + GMP – ''Tritrichomonas foetus''<br />
-
**[[1qk3]] - TgHGPRT + GMP<br />
+
**[[1qk3]] - TgHPRT + GMP<br />
-
**[[1qk4]] - TgHGPRT + IMP<BR />
+
**[[1qk4]] - TgHPRT + IMP<BR />
-
**[[1p19]] - TcHGPRT + IMP<BR />
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**[[1p19]] - TcHPRT + IMP<BR />
-
**[[1p17]] - TcHGPRT (mutant) + IMP<BR />
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**[[1p17]] - TcHPRT (mutant) + IMP<BR />
-
**[[1yfz]] - TteHGPRT + IMP<BR />
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**[[1yfz]] - TteHPRT + IMP<BR />
-
**[[1dqp]] - GiHGPRT + imucillin – ''Giardia intestinalis''<br />
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**[[1dqp]] - GiHPRT + imucillin – ''Giardia intestinalis''<br />
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**[[1pzm]] - LtHGPRT + GMP – ''Leishmania tarentolae''<br />
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**[[1pzm]] - LtHPRT + GMP – ''Leishmania tarentolae''<br />
-
**[[1y0b]] - BsHGPRT + GTP – ''Bacillus subtilis''<br />
+
**[[1y0b]] - BsHPRT + GTP – ''Bacillus subtilis''<br />
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**[[2fxv]] - BsHGPRT + GMP<br />
+
**[[2fxv]] - BsHPRT + GMP<br />
-
**[[3kb8]] - BaHGPRT + GMP<br />
+
**[[3kb8]] - BaHPRT + GMP<br />
-
**[[2jky]], [[2jkz]], [[2xbu]] - yHGPRT + GMP<br />
+
**[[2jky]], [[2jkz]], [[2xbu]] - yHPRT + GMP<br />
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**[[3acc]] - TtHGPRT + GMP<br />
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**[[3acc]] - TtHPRT + GMP<br />
-
**[[3acd]] - TtHGPRT + IMP<BR />
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**[[3acd]] - TtHPRT + IMP<BR />
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**[[1cjb]] - PfHGPRT + pyrophosphate <br />
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**[[1cjb]] - PfHPRT + pyrophosphate <br />
-
**[[3ozf]] - PfHGPRT + hypoxanthine<br />
+
**[[3ozf]] - PfHPRT + hypoxanthine<br />
-
**[[3ozg]] - PfHGPRT + inhibitor<br />
+
**[[3ozg]] - PfHPRT + inhibitor<br />
-
**[[1dqn]] - GiHGPRT + transition state analog<br />
+
**[[1dqn]] - GiHPRT + transition state analog<br />
-
**[[1d6n]] - LdAPRT + AMP derivative<br />
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**[[1d6n]] - LdHPRT + AMP derivative<br />
-
**[[4z1o]] - SsHGPRT + PRPP - ''Sulfolobus solfataricus''<br />
+
**[[4z1o]] - SsHPRT + PRPP - ''Sulfolobus solfataricus''<br />
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**[[4zfn]] - SsHGPRT + GMP<br />
+
**[[4zfn]] - SsHPRT + GMP<br />
*Hypoxanthine-guanine phosphoribosyltransferase ternary complex
*Hypoxanthine-guanine phosphoribosyltransferase ternary complex
-
**[[1a95]] - EcHGPRT + guanine + PRPP derivative<br />
+
**[[1a95]] - EcHPRT + guanine + PRPP derivative<br />
-
**[[1a96]] - EcHGPRT + xanthine + PRPP derivative<br />
+
**[[1a96]] - EcHPRT + xanthine + PRPP derivative<br />
-
**[[1bzy]] - hHGPRT + inhibitor + guanine derivative<br />
+
**[[1bzy]] - hHPRT + inhibitor + guanine derivative<br />
-
**[[1tc2]], [[1i0i]], [[1i0l]], [[1i13]], [[1i14]] – TcHGPRT + pyrimidine derivative + PRPP derivative<br />
+
**[[1tc2]], [[1i0i]], [[1i0l]], [[1i13]], [[1i14]] – TcHPRT + pyrimidine derivative + PRPP derivative<br />
-
**[[1p18]] - TcHGPRT (mutant) + pyrimidine derivative + PRPP<BR />
+
**[[1p18]] - TcHPRT (mutant) + pyrimidine derivative + PRPP<BR />
-
**[[1qk5]] - TgHGPRT (mutant) + XMP + pyrophosphate<br />
+
**[[1qk5]] - TgHPRT (mutant) + XMP + pyrophosphate<br />
-
**[[1fsg]] - TgHGPRT + guanine derivative + PRPP<BR />
+
**[[1fsg]] - TgHPRT + guanine derivative + PRPP<BR />
-
**[[1cjb]] - PfHGPRT + pyrophosphate + inhibitor<br />
+
**[[1cjb]] - PfHPRT + pyrophosphate + inhibitor<br />
*'''Quinolinic acid phosphoribosyltransferase'''
*'''Quinolinic acid phosphoribosyltransferase'''

Revision as of 08:56, 30 June 2016

Template:STRUCTURE 3l0k

Function

Phosphoribosyltransferase (PRT) are transferases which belong to several classes:
1. Hypoxanthine-guanine PRT (HPRT). HPRT is part of the purine biosynthesis and catalyzes the formation of GMP from guanine, xanthosine monophosphate from xanthosine and of inosine monophosphate from hypoxanthine.
2. Orotate PRT (OPRT). OPRT is part of the pyrimidine biosynthesis and catalyzes the formation of orotidine 5’-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate (PRPP).
3. Quinolinic acid PRT (QAPRT ). QAPRT is a degrading enzyme found in the brain.
4. Uracil PRT (UPRT). UPRT catalyzes the formation of UMP from uracil and PRPP. Adenine PRT (APRT). APRT catalyzes the formation of AMP from adenine and PRPP.
5. Nicotinate nucleotide dimethylbenzimidazole PRT (NN:DBI PRT). NN:DBI PRT is part of riboflavin, porphyrin and chlorophyll biosynthesis.
6. Anthranilate PRT (ANPRT). ANPRT participates in phenylalanine, tyrosine and tryptophan biosynthesis and catalyzes the formation of anthraniline from phosphoribosyl anthranilate.
7. ATP PRT participates in histidine biosynthesis and catalyzes the formation of ATP from phosphoribosyl ATP and diphosphate.
8. Nicotinate PRT (NIPRT). NIPRT catalyzes the formation of nicotinate from nicotinate ribonucleotide and diphosphate.
9. Nicotinamide PRT (NMPRT). NMPRT catalyzes the formation of nicotinamide from nicotinamide ribonucleotide (NMN) and diphosphate.

Disease

</StructureSection>

3D structures of phosphoribosyltransferase

Updated on 30-June-2016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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