Phosphoserine aminotransferase
From Proteopedia
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{{STRUCTURE_1bjo| PDB=1bjo | SIZE=400| SCENE= |right|CAPTION=E. coli phosphoserine aminotransferase dimer complex with pyridoxal phosphate and glutamate [[1bjo]] }} | {{STRUCTURE_1bjo| PDB=1bjo | SIZE=400| SCENE= |right|CAPTION=E. coli phosphoserine aminotransferase dimer complex with pyridoxal phosphate and glutamate [[1bjo]] }} | ||
| - | + | == Function == | |
| - | + | '''Phosphoserine aminotransferase''' (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT. | |
| - | + | ||
| - | + | == Relevance == | |
| - | + | PSAT is over-expressed in colon tumors and its inhibition is being tested as drug treatment. | |
| - | '''Phosphoserine aminotransferase''' (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT. PSAT is over-expressed in colon tumors and its inhibition is being tested as drug treatment. | + | |
==3D structures of phosphoserine aminotransferase== | ==3D structures of phosphoserine aminotransferase== | ||
Revision as of 09:45, 30 June 2016
Function
Phosphoserine aminotransferase (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT.
Relevance
PSAT is over-expressed in colon tumors and its inhibition is being tested as drug treatment.
3D structures of phosphoserine aminotransferase
Updated on 30-June-2016
