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4zke

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'''Unreleased structure'''
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==Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GTP.==
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<StructureSection load='4zke' size='340' side='right' caption='[[4zke]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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The entry 4zke is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zke]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKE FirstGlance]. <br>
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Authors: Kowalinski, E., Conti, E.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zke RCSB], [http://www.ebi.ac.uk/pdbsum/4zke PDBsum]</span></td></tr>
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Description: Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GTP.
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Kowalinski, E]]
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[[http://www.uniprot.org/uniprot/SKI7_YEAST SKI7_YEAST]] Represses the expression of non-poly(A) mRNAs like L-A or M viruses and is therefore involved in antiviral system. Mediates interactions via its N-terminus between the exosome and the SKI complex which operate in the 3'-to-5' mRNA-decay pathway. By interacting with NAM7, is also required for nonsense-mediated 3'-to-5' mRNA-decay (NMD). May recognize a stalled 80S ribosome at the 3'-end of a nonstop mRNA which leads to the recruitment of the exosome and SKI complexes to the mRNAs to be degraded.<ref>PMID:10074137</ref> <ref>PMID:11027292</ref> <ref>PMID:11514438</ref> <ref>PMID:11532933</ref> <ref>PMID:11910110</ref> <ref>PMID:12769863</ref> <ref>PMID:12881429</ref> <ref>PMID:14671320</ref> <ref>PMID:15933721</ref> <ref>PMID:6371496</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Conti, E]]
[[Category: Conti, E]]
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[[Category: Kowalinski, E]]
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[[Category: Gtp binding protein]]
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[[Category: Gtpase]]
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[[Category: Hydrolase]]
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[[Category: Ngd]]
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[[Category: Ski]]
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[[Category: Translation]]

Revision as of 15:32, 17 June 2015

Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GTP.

4zke, resolution 2.25Å

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