4zlx
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==N-terminal DNA binding domain of the antitoxin Phd from phage P1== | |
| - | + | <StructureSection load='4zlx' size='340' side='right' caption='[[4zlx]], [[Resolution|resolution]] 2.31Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zlx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZLX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlx OCA], [http://pdbe.org/4zlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zlx RCSB], [http://www.ebi.ac.uk/pdbsum/4zlx PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PHD_BPP1 PHD_BPP1]] Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that binds to the doc toxin and neutralizes its toxic effect. Bacteriophage P1 lysogenizes bacteria as a low-copy number plasmid. Phd and doc proteins function in unison to stabilize plasmid number by inducing a lethal response to P1 plasmid prophage loss.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref> Binds to its own promoter repressing its expression; toxin doc acts as a corepressor or derepressor depending on the ratio, repressing or inducing expression.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Garcia-Pino, A]] | [[Category: Garcia-Pino, A]] | ||
[[Category: Loris, R]] | [[Category: Loris, R]] | ||
| + | [[Category: Conditional cooperativity]] | ||
| + | [[Category: Dna binding]] | ||
| + | [[Category: Intrinsic disorder]] | ||
| + | [[Category: Toxin-antitoxin]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription factor]] | ||
Revision as of 17:58, 10 May 2016
N-terminal DNA binding domain of the antitoxin Phd from phage P1
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