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Cytochrome P450

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* P450 from ''Mycobacterium tuberculosis''
* P450 from ''Mycobacterium tuberculosis''
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**[[2vku]], [[1h5z]] – MtP45051 - ''Mycobacterium tuberculosis''<br />
+
**[[2vku]], [[1h5z]] – MtP450 CYP51 - ''Mycobacterium tuberculosis''<br />
-
**[[2ci0]], [[2cib]], [[1u13]] - MtP45051 (mutant)<br />
+
**[[2ci0]], [[2cib]], [[1u13]] - MtP450 CYP51 (mutant)<br />
-
**[[1x8v]] - MtP45051 (mutant)+estriol<br />
+
**[[1x8v]] - MtP450 CYP51 (mutant)+estriol<br />
-
**[[1ea1]] - MtP45051 (mutant)+ fluconazole<br />
+
**[[1ea1]] - MtP450 CYP51 (mutant)+ fluconazole<br />
-
**[[1e9x]] - MtP45051 (mutant)+ phenylimidazole<br />
+
**[[1e9x]] - MtP450 CYP51 (mutant)+ phenylimidazole<br />
-
**[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtP450121 (mutant)<br />
+
**[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtP450 CYP121 (mutant)<br />
-
**[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtP450121<br />
+
**[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtP450 CYP121<br />
-
**[[2ij7]] - MtP450121+fluconazole<br />
+
**[[2ij7]] - MtP450 CYP121+fluconazole<br />
-
**[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]] - MtP450121+pyrazole derivative<br />
+
**[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]] - MtP450 CYP121+pyrazole derivative<br />
-
**[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]] - MtP450121 + piperazine derivative<br />
+
**[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]] - MtP450 CYP121 + piperazine derivative<br />
-
**[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]] - MtP450121 + inhibitor<br />
+
**[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]] - MtP450 CYP121 + inhibitor<br />
-
**[[3ivi]], [[3iw0]], [[3ivy]] – MtP450125 <br />
+
**[[3ivi]], [[3iw0]], [[3ivy]] – MtP450 CYP125 <br />
-
**[[3iw1]] - MtP450125+androstenedione<br />
+
**[[3iw1]] - MtP450 CYP125+androstenedione<br />
-
**[[3iw2]] - MtP450125+econazole<br />
+
**[[3iw2]] - MtP450 CYP125+econazole<br />
-
**[[2uvn]] - MtP450130+econazole<br />
+
**[[2uvn]] - MtP450 CYP130+econazole<br />
-
**[[2wgy]] – MtP450130 (mutant)<br />
+
**[[2wgy]] – MtP450 CYP130 (mutant)<br />
-
**[[2w09]], [[2w0b]], [[2w0a]] - MtP450130 (mutant)+pyridine inhibitor<br />
+
**[[2w09]], [[2w0b]], [[2w0a]] - MtP450 CYP130 (mutant)+pyridine inhibitor<br />
-
**[[2uuq]] – MtP450130
+
**[[2uuq]] – MtP450 CYP130
* P450cam
* P450cam

Revision as of 10:00, 2 July 2015

Template:STRUCTURE 2f9q

Cytochrome P450 (P450) catalyzes the oxidation of organic substances like lipids. catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene. For details on the human P45019 family see Aromatase.

  • P450cam, also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor.
  • P450nor is a Nitric Oxide Reductase P450.
  • P450epoK converts epothilone D to epothilone B.
  • P450cin monooxygenates 1,8-cineole which is similar to camphor.
  • Bifunctional P450/NADPH P450 reductase (P450 BM3) is a fatty acid monooxygenase.

Additional details in Drug Metabolism by CYP450 Enzymes.

3D Structures of Cytochrome P450

Updated on 02-July-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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