4zrq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==E88 deletion mutant of CD320 in complex with TC2== | |
| - | + | <StructureSection load='4zrq' size='340' side='right' caption='[[4zrq]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zrq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CNC:CO-CYANOCOBALAMIN'>CNC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zrp|4zrp]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zrq OCA], [http://pdbe.org/4zrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zrq RCSB], [http://www.ebi.ac.uk/pdbsum/4zrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zrq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[http://omim.org/entry/275350 275350]]. This results in various forms of anemia. [[http://www.uniprot.org/uniprot/CD320_HUMAN CD320_HUMAN]] Methylmalonic aciduria due to transcobalamin receptor defect. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. [[http://www.uniprot.org/uniprot/CD320_HUMAN CD320_HUMAN]] Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.<ref>PMID:11418631</ref> <ref>PMID:18779389</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Alam, A]] | [[Category: Alam, A]] | ||
| - | [[Category: Locher, K | + | [[Category: Locher, K P]] |
| + | [[Category: Ldlr-r]] | ||
| + | [[Category: Transport protein]] | ||
| + | [[Category: Vitamin transporter]] | ||
Revision as of 15:24, 26 July 2016
E88 deletion mutant of CD320 in complex with TC2
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