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| - | ==Structure and function of the JAK interaction region in the intrinsically disordered N-terminus of SOCS5==
| + | #REDIRECT [[2n34]] This PDB entry is obsolete and replaced by 2n34 |
| - | <StructureSection load='2mp6' size='340' side='right' caption='[[2mp6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[2mp6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MP6 FirstGlance]. <br>
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| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mp6 RCSB], [http://www.ebi.ac.uk/pdbsum/2mp6 PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/SOCS5_MOUSE SOCS5_MOUSE]] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.<ref>PMID:12242343</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Babon, J J]]
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| - | [[Category: Chandrashekaran, I R]]
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| - | [[Category: Dagley, L F]]
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| - | [[Category: Linossi, E M]]
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| - | [[Category: Mohanty, B]]
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| - | [[Category: Murphy, J M]]
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| - | [[Category: Nicholson, S E]]
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| - | [[Category: Norton, R S]]
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| - | [[Category: Cytokine signalling suppressor]]
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| - | [[Category: Intrinsically unstructured protein]]
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| - | [[Category: Jak interaction region]]
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| - | [[Category: Signaling protein]]
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