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Proteasome
From Proteopedia
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{{STRUCTURE_3gpt| PDB=3gpt | SIZE=400| SCENE= |right|CAPTION=Proteasome complex with salinosporamide derivative, [[3gpt]] }} | {{STRUCTURE_3gpt| PDB=3gpt | SIZE=400| SCENE= |right|CAPTION=Proteasome complex with salinosporamide derivative, [[3gpt]] }} | ||
| - | [[Proteasome]] (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 α subunits which form the PRTS gate. The two inner rings contain 6 β subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin. | + | [[Proteasome]] (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 α subunits which form the PRTS gate. The two inner rings contain 6 β subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin. <br /> |
| + | For more details see [[3unb]]. | ||
== 3D Structures of Proteasome == | == 3D Structures of Proteasome == | ||
Revision as of 12:56, 4 January 2016
Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 α subunits which form the PRTS gate. The two inner rings contain 6 β subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin.
For more details see 3unb.
3D Structures of Proteasome
Updated on 04-January-2016
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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
