Protein kinase C
From Proteopedia
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<StructureSection load='3gpe' size='350' side='right' caption='Rat protein kinase a C2 domain complex with phosphatidylinositol, phosphate and Ca+2 ion (green), [[3gpe]] ' scene=''> | <StructureSection load='3gpe' size='350' side='right' caption='Rat protein kinase a C2 domain complex with phosphatidylinositol, phosphate and Ca+2 ion (green), [[3gpe]] ' scene=''> | ||
| - | '''Protein kinase C''' (PKC) phosphorylate serine or threonine residues in proteins. They act in signal transduction pathways. Conventional PKC (CPKC) - α, β1, β2, γ – are activated by diacylglycerol (DAG), Ca+2 and a phospholipid. Novel PKC (NPKC) – δ, ε, η, θ – are activated by DAG. Atypical (APKC) do not require DAG or Ca+2 for activation. PKC consists of regulatory domain hinged to a catalytic domain. The regulatory domain contains the C1 region which binds DAG and phorbol esters and the C2 domain which is a Ca+2 sensor. PKC contains Pleckstrin Homology (PH) domain which binds phosphatidylinositol lipids (PTDINS). The PH domain is found in proteins involved in intracellular signaling. | + | '''Protein kinase C''' (PKC) phosphorylate serine or threonine residues in proteins. They act in signal transduction pathways. '''Conventional PKC''' (CPKC) - α, β1, β2, γ – are activated by diacylglycerol (DAG), Ca+2 and a phospholipid. '''Novel PKC''' (NPKC) – δ, ε, η, θ – are activated by DAG. '''Atypical PKC''' (APKC) do not require DAG or Ca+2 for activation. PKC consists of regulatory domain hinged to a catalytic domain. The regulatory domain contains the C1 region which binds DAG and phorbol esters and the C2 domain which is a Ca+2 sensor. PKC contains Pleckstrin Homology (PH) domain which binds phosphatidylinositol lipids (PTDINS). The PH domain is found in proteins involved in intracellular signaling. |
</StructureSection> | </StructureSection> | ||
==3D structures of protein kinase C== | ==3D structures of protein kinase C== | ||
Revision as of 08:43, 21 May 2015
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3D structures of protein kinase C
Updated on 21-May-2015
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
