Protein kinase C
From Proteopedia
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<StructureSection load='3gpe' size='350' side='right' caption='Rat protein kinase a C2 domain complex with phosphatidylinositol, phosphate and Ca+2 ion (green), [[3gpe]] ' scene=''> | <StructureSection load='3gpe' size='350' side='right' caption='Rat protein kinase a C2 domain complex with phosphatidylinositol, phosphate and Ca+2 ion (green), [[3gpe]] ' scene=''> | ||
| - | '''Protein kinase C''' (PKC) | + | == Function == |
| + | '''Protein kinase C''' (PKC) phosphorylates serine or threonine residues in proteins. PKC act in signal transduction pathways<ref>PMID:11440359</ref>. PKC consists of regulatory domain hinged to a catalytic domain. The regulatory domain contains the C1 region which binds diacylglycerol (DAG) and phorbol esters and the C2 domain which is a Ca+2 sensor. PKC contains Pleckstrin Homology (PH) domain which binds phosphatidylinositol lipids (PTDINS). The PH domain is found in proteins involved in intracellular signaling. | ||
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| + | *'''Conventional PKC''' (CPKC) - α, β1, β2, γ – are activated by DAG, Ca+2 and a phospholipid.<br /> | ||
| + | *'''Novel PKC''' (NPKC) – δ, ε, η, θ – are activated by DAG.<br /> | ||
| + | *'''Atypical PKC''' (APKC) do not require DAG or Ca+2 for activation. | ||
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| + | == Relevance == | ||
| + | Activation of PKC and elevated levels of DAG are associated with vascular abnormalities in retinal, renal and cardiovascular tissues. Inhibitors of PKC-β are tested for prevention of diabetic complications<ref>PMID:9604860</ref>. Activation of PKC-α and PKC-β are linked to malignant phenotypes while PKC-δ is thought to mediate anti-cancer effects<ref>PMID:15907369</ref>. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of protein kinase C== | ==3D structures of protein kinase C== | ||
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*'''Conventional PKCs''' | *'''Conventional PKCs''' | ||
| - | *PKC- | + | *PKC-α |
**[[1dsy]], [[3rdj]], [[3twy]] – rCPKC-α C2 domain – rat | **[[1dsy]], [[3rdj]], [[3twy]] – rCPKC-α C2 domain – rat | ||
Revision as of 09:06, 14 July 2016
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3D structures of protein kinase C
Updated on 14-July-2016
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
