Proto-oncogene serine/threonine-protein kinase
From Proteopedia
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{{STRUCTURE_3cy2| PDB=3cy2 | SIZE=350| SCENE= |right|CAPTION=Pim-1 (grey) complex with consensus peptide (green), inhibitor and Cl- ion [[3cy2]] }} | {{STRUCTURE_3cy2| PDB=3cy2 | SIZE=350| SCENE= |right|CAPTION=Pim-1 (grey) complex with consensus peptide (green), inhibitor and Cl- ion [[3cy2]] }} | ||
| - | '''Proto-oncogene serine/threonine-protein kinase (Pim1)''' is implicated with a variety of cancers. Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signaling pathways. Pim1 phosphorylates and inhibits proapoptotic proteins. Pim1 is phosphorylated on serine 261 (PSer). The consensus peptide (pimtide) ARKRRRHPSGPPTA binds strongly to Pim1. | + | '''Proto-oncogene serine/threonine-protein kinase (Pim1)''' is implicated with a variety of cancers. Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signaling pathways. Pim1 phosphorylates and inhibits proapoptotic proteins. Pim1 is phosphorylated on serine 261 (PSer). The consensus peptide (pimtide) ARKRRRHPSGPPTA binds strongly to Pim1. For details see [[Student Project 6 for UMass Chemistry 423 Spring 2015]]. |
== 3D Structures of pim-1 == | == 3D Structures of pim-1 == | ||
Revision as of 09:49, 22 February 2016
Proto-oncogene serine/threonine-protein kinase (Pim1) is implicated with a variety of cancers. Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signaling pathways. Pim1 phosphorylates and inhibits proapoptotic proteins. Pim1 is phosphorylated on serine 261 (PSer). The consensus peptide (pimtide) ARKRRRHPSGPPTA binds strongly to Pim1. For details see Student Project 6 for UMass Chemistry 423 Spring 2015.
3D Structures of pim-1
Updated on 22-February-2016
