VEGF IN COMPLEX WITH A NEUTRALIZING ANTIBODY
From Proteopedia
(Difference between revisions)
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| - | <scene name='70/701451/Antibodies_fragment_chains/3'>VEGF antibodies chains</scene> | ||
| - | <ref>PMID 9753694</ref> | ||
| - | '''VEGF IN COMPLEX WITH A NEUTRALIZING ANTIBODY''' | ||
| + | <ref>PMID 9753694</ref> | ||
| + | This is a default text for your page '''VEGF IN COMPLEX WITH A NEUTRALIZING ANTIBODY'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| + | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name='maor vegf'>PMID:21638687</ref> to the rescue. | ||
== Backround == | == Backround == | ||
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VEGF and anti-VEGF Fab Complex is a 6 chain, 1050 amino acid structure with a sequence taken from Homo sapiens and Mus musculus. | VEGF and anti-VEGF Fab Complex is a 6 chain, 1050 amino acid structure with a sequence taken from Homo sapiens and Mus musculus. | ||
For a guided tour on the structure components use[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ1 FirstGlance] | For a guided tour on the structure components use[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ1 FirstGlance] | ||
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VEGF is a <scene name='70/701451/Homodimeric_vegf/1'>homodimeric</scene> protein who belongs to the family of cystine knot growth factors. | VEGF is a <scene name='70/701451/Homodimeric_vegf/1'>homodimeric</scene> protein who belongs to the family of cystine knot growth factors. | ||
while the 4 other chains belongs to the <scene name='70/701451/1bj1_fab_fragment_emphesys/1'>FAB fragment</scene>. | while the 4 other chains belongs to the <scene name='70/701451/1bj1_fab_fragment_emphesys/1'>FAB fragment</scene>. | ||
| - | + | VEGF and anti-VEGF Fab Complex | |
The structure of the <scene name='70/701451/Receptor_binding_domain/1'>receptor-binding domain</scene> (residues 8–109) of VEGF consists of a central four- stranded β sheet that displays the characteristic cystine knot at one end and possesses a small hydrophobic core at the other end. | The structure of the <scene name='70/701451/Receptor_binding_domain/1'>receptor-binding domain</scene> (residues 8–109) of VEGF consists of a central four- stranded β sheet that displays the characteristic cystine knot at one end and possesses a small hydrophobic core at the other end. | ||
| + | == Overall Structure == | ||
Revision as of 17:33, 24 May 2015
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References
- ↑ Muller YA, Chen Y, Christinger HW, Li B, Cunningham BC, Lowman HB, de Vos AM. VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface. Structure. 1998 Sep 15;6(9):1153-67. PMID:9753694
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
