Purine nucleoside phosphorylase
From Proteopedia
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<StructureSection load='1v2h' size='350' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene=''> | <StructureSection load='1v2h' size='350' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene=''> | ||
| - | + | == Function == | |
| - | '''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down. PNP deficiency results in severe combined immunodeficiency. | + | '''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down. |
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| + | == Disease == | ||
| + | PNP deficiency results in severe combined immunodeficiency<ref>PMID:1931007</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br /> | **[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br /> | ||
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| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:10, 31 July 2016
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3D structures of purine nucleoside phosphorylase
Updated on 31-July-2016
References
- ↑ Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425. PMID:11337031
- ↑ Markert ML. Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81. PMID:1931007
