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Pyruvate dehydrogenase kinase
From Proteopedia
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{{STRUCTURE_1jm6| PDB=1jm6 | SIZE=400| SCENE= |right|CAPTION=Rat pyruvate dehydrogenase kinase isozyme 2 dimer complex with ADP (stick model) and Mg+2 ion (green) [[1jm6]] }} | {{STRUCTURE_1jm6| PDB=1jm6 | SIZE=400| SCENE= |right|CAPTION=Rat pyruvate dehydrogenase kinase isozyme 2 dimer complex with ADP (stick model) and Mg+2 ion (green) [[1jm6]] }} | ||
| - | + | == Function == | |
| - | + | '''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>. | |
| - | + | ||
| - | + | == Relevance == | |
| - | + | Inhibition of PDK decreases the damage caused by heart ischemia and are used in diabetes and cancer patients<ref>PMID:17310282</ref><ref>PMID:23471124</ref>. | |
| - | '''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites. | + | |
==3D structures of pyruvate dehydrogenase kinase== | ==3D structures of pyruvate dehydrogenase kinase== | ||
Revision as of 10:04, 2 August 2016
Function
Pyruvate dehydrogenase kinase (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites[1].
Relevance
Inhibition of PDK decreases the damage caused by heart ischemia and are used in diabetes and cancer patients[2][3].
3D structures of pyruvate dehydrogenase kinase
Updated on 02-August-2016
