Retinoblastoma-binding protein

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{{STRUCTURE_3cfs| PDB=3cfs | SIZE=400| SCENE=|right|CAPTION=Human retinoblastoma-binding protein 7 (green) complex with histone H4 helix (magenta) and As ion (purple) [[3cfs]] }}
{{STRUCTURE_3cfs| PDB=3cfs | SIZE=400| SCENE=|right|CAPTION=Human retinoblastoma-binding protein 7 (green) complex with histone H4 helix (magenta) and As ion (purple) [[3cfs]] }}
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'''Retinoblastoma-binding protein''' (RBBP) or '''histone-binding protein''' are nuclear proteins implicated in the regulation of transcription and differentiation by the retinoblastoma tumor suppressor protein<ref>PMID:9697699</ref>.<br />
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* '''RBBP1''' regulates transcriptional activity<ref>PMID:8414517</ref>.<br />
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'''Retinoblastoma-binding protein''' (RBBP) or '''histone-binding protein''' are nuclear proteins implicated in the regulation of transcription and differentiation by the retinoblastoma tumor suppressor protein.<br />
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* '''RBBP1''' regulates transcriptional activity.<br />
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* '''RBBP2''' demethylates histone H3 at lysine 4.<br />
* '''RBBP2''' demethylates histone H3 at lysine 4.<br />
* '''RBBP5''' is involved in methylation and dimethylation of histone H3.<br />
* '''RBBP5''' is involved in methylation and dimethylation of histone H3.<br />
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* '''RBBP9''' blocks the binding of retinoblastoma protein to one of its signaling partners.
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* '''RBBP6''' promotes p53 degradation<ref>PMID:21676486</ref>.<br />
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* '''RBBP7''' is a WD-repeat protein that interacts with histone deacetylases<ref>PMID:12376095</ref>.<br />
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* '''RBBP9''' blocks the binding of retinoblastoma protein to one of its signaling partners<ref>PMID:21933118</ref>.<br />.
==3D structures of retinoblastoma-binding protein==
==3D structures of retinoblastoma-binding protein==
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**[[2qs9]] – hRBBP9
**[[2qs9]] – hRBBP9
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:00, 7 August 2016

Template:STRUCTURE 3cfs


Retinoblastoma-binding protein (RBBP) or histone-binding protein are nuclear proteins implicated in the regulation of transcription and differentiation by the retinoblastoma tumor suppressor protein[1].

  • RBBP1 regulates transcriptional activity[2].
  • RBBP2 demethylates histone H3 at lysine 4.
  • RBBP5 is involved in methylation and dimethylation of histone H3.
  • RBBP6 promotes p53 degradation[3].
  • RBBP7 is a WD-repeat protein that interacts with histone deacetylases[4].
  • RBBP9 blocks the binding of retinoblastoma protein to one of its signaling partners[5].
    .

3D structures of retinoblastoma-binding protein

Updated on 07-August-2016

References

  1. ↑ Woitach JT, Zhang M, Niu CH, Thorgeirsson SS. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat Genet. 1998 Aug;19(4):371-4. PMID:9697699 doi:http://dx.doi.org/10.1038/1258
  2. ↑ Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, et al.. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene. 1993 Nov;8(11):3149-56. PMID:8414517
  3. ↑ Motadi LR, Bhoola KD, Dlamini Z. Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer. Immunobiology. 2011 Oct;216(10):1065-73. doi: 10.1016/j.imbio.2011.05.004. Epub, 2011 May 17. PMID:21676486 doi:http://dx.doi.org/10.1016/j.imbio.2011.05.004
  4. ↑ Yang J, Kiefer S, Rauchman M. Characterization of the gene encoding mouse retinoblastoma binding protein-7, a component of chromatin-remodeling complexes. Genomics. 2002 Oct;80(4):407-15. PMID:12376095
  5. ↑ Vorobiev SM, Huang YJ, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L. Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers. Protein Pept Lett. 2012 Feb;19(2):194-7. PMID:21933118

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