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4zvj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human triose phosphate isomerase K13M== | |
| - | + | <StructureSection load='4zvj' size='340' side='right' caption='[[4zvj]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zvj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZVJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvj OCA], [http://pdbe.org/4zvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zvj RCSB], [http://www.ebi.ac.uk/pdbsum/4zvj PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[http://omim.org/entry/190450 190450]]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Triose-phosphate isomerase]] | ||
| + | [[Category: Amrich, C G]] | ||
| + | [[Category: Heroux, A]] | ||
[[Category: Smith, C]] | [[Category: Smith, C]] | ||
| - | [[Category: | + | [[Category: VanDemark, A P]] |
| - | [[Category: | + | [[Category: Dimer]] |
| - | [[Category: | + | [[Category: Glycolysis]] |
| + | [[Category: Isomerase]] | ||
| + | [[Category: Tim]] | ||
| + | [[Category: Triose phosphate isomerase]] | ||
Revision as of 03:51, 10 March 2016
Structure of human triose phosphate isomerase K13M
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