Ribosomal protein S19
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_2v7f| PDB=2v7f | SIZE=400| SCENE= |right|CAPTION=Ribosomal protein S19 complex with Cl- ion [[2v7f]] }} | {{STRUCTURE_2v7f| PDB=2v7f | SIZE=400| SCENE= |right|CAPTION=Ribosomal protein S19 complex with Cl- ion [[2v7f]] }} | ||
| + | == Function == | ||
| + | [[Ribosomal protein S19]] (RPS19) is one of the 21 proteins which belong to the 30S <scene name='Ribosomal_protein_S19/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It forms a complex with RPS13 that binds to 16S RRNA<ref>PMID:8722009</ref>. | ||
| - | + | == Relevance == | |
| + | RPS19 is a potent anti-inflammatory agent which appears to work primarily by inhibiting MIF signaling<ref>PMID:23252627</ref>. | ||
== 3D Structures of Ribosomal protein S19 == | == 3D Structures of Ribosomal protein S19 == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | ===S19=== | ||
[[2v7f]] – RPS19 – ''Pyroccocus abyssi''<br /> | [[2v7f]] – RPS19 – ''Pyroccocus abyssi''<br /> | ||
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[[3a1p]] – TtRPS19 + ribosome maturation factor<br /> | [[3a1p]] – TtRPS19 + ribosome maturation factor<br /> | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:34, 16 August 2016
Contents |
Function
Ribosomal protein S19 (RPS19) is one of the 21 proteins which belong to the 30S of the bacterial ribosome or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It forms a complex with RPS13 that binds to 16S RRNA[1].
Relevance
RPS19 is a potent anti-inflammatory agent which appears to work primarily by inhibiting MIF signaling[2].
3D Structures of Ribosomal protein S19
Updated on 16-August-2016
2v7f – RPS19 – Pyroccocus abyssi
1qkh, 1qkf - TtRPS19 - Thermus thermophilus – NMR
3a1p – TtRPS19 + ribosome maturation factor
References
- ↑ Wool IG, Chan YL, Gluck A. Structure and evolution of mammalian ribosomal proteins. Biochem Cell Biol. 1995 Nov-Dec;73(11-12):933-47. PMID:8722009
- ↑ Lv J, Huang XR, Klug J, Frohlich S, Lacher P, Xu A, Meinhardt A, Lan HY. Ribosomal protein S19 is a novel therapeutic agent in inflammatory kidney disease. Clin Sci (Lond). 2013 May;124(10):627-37. doi: 10.1042/CS20120526. PMID:23252627 doi:http://dx.doi.org/10.1042/CS20120526
