4zmj

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'''Unreleased structure'''
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==Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer==
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<StructureSection load='4zmj' size='340' side='right' caption='[[4zmj]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
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The entry 4zmj is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>
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Authors: Kwon, Y.D., Kwong, P.D.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [http://www.ebi.ac.uk/pdbsum/4zmj PDBsum]</span></td></tr>
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Description: Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Kwon, Y.D]]
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[[http://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
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[[Category: Kwong, P.D]]
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__TOC__
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</StructureSection>
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[[Category: Kwon, Y D]]
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[[Category: Kwong, P D]]
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[[Category: Bg505 sosip]]
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[[Category: Env trimer]]
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[[Category: Hiv-1]]
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[[Category: Unliganded]]
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[[Category: Viral protein]]

Revision as of 13:04, 24 June 2015

Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer

4zmj, resolution 3.31Å

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