Adrenodoxin reductase

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Adrenodoxin reductase (AR) is the first enzyme in the mitochondrial P450 systems that are expressed in tissues that synthesize steroids.<ref name="HI-review">PMID:22217824</ref> AR is an FAD containing flavoprotein that receives two electrons from NADPH and transfers them one at time to adrenodoxin that is an iron sulfur protein. Reduced adrenodoxin in turn reduces mitochondrial P450s that catalyze essential steps in the biosynthesis of steroids, such as pregnenolone, cortisol, aldosterone and sex steroids.<ref name="HI-review" />
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Adrenodoxin reductase (AR) is an FAD containing flavoprotein that function as an electron transfer protein in the mitochondrial P450 systems that catalyze essential steps in biosynthesis of steroid hormones.<ref name="HI-review">PMID:22217824</ref>. Its enzyme nomenclature code is [http://www.chem.qmul.ac.uk/iubmb/enzyme/EC1/18/1/6.html 1.18.1.6].
==References==
==References==

Revision as of 17:56, 4 June 2015

Adrenodoxin reductase (AR) is an FAD containing flavoprotein that function as an electron transfer protein in the mitochondrial P450 systems that catalyze essential steps in biosynthesis of steroid hormones.[1]. Its enzyme nomenclature code is 1.18.1.6.

References

  1. ↑ Hanukoglu I. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. J Steroid Biochem Mol Biol. 1992 Dec;43(8):779-804. doi:, 10.1016/0960-0760(92)90307-5. PMID:22217824 doi:http://dx.doi.org/10.1016/0960-0760(92)90307-5

See Also

Adrenodoxin reductase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Israel Hanukoglu, Michal Harel, Joel L. Sussman

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