4zw1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer== | |
| - | + | <StructureSection load='4zw1' size='340' side='right' caption='[[4zw1]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zw1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZW1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4V1:2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-7-METHYL-5,6,7,8-TETRAHYDROPYRIDO[4,3 4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>4V1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zw1 OCA], [http://pdbe.org/4zw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zw1 RCSB], [http://www.ebi.ac.uk/pdbsum/4zw1 PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Guo, M]] | [[Category: Guo, M]] | ||
| - | [[Category: Zhang, S]] | ||
[[Category: Liu, B]] | [[Category: Liu, B]] | ||
[[Category: Tian, M]] | [[Category: Tian, M]] | ||
| + | [[Category: Zhang, S]] | ||
| + | [[Category: Chromatin reader protein]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Transcription regulation]] | ||
| + | [[Category: Transcription-inhibitor complex]] | ||
Revision as of 23:21, 23 June 2016
Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer
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