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5a34

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'''Unreleased structure'''
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==The crystal structure of the GST-like domains complex of EPRS-AIMP2==
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<StructureSection load='5a34' size='340' side='right' caption='[[5a34]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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The entry 5a34 is ON HOLD until May 27 2017
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5a34]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A34 FirstGlance]. <br>
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Authors: Cho, H.Y., Kang, B.S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a34 OCA], [http://pdbe.org/5a34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a34 RCSB], [http://www.ebi.ac.uk/pdbsum/5a34 PDBsum]</span></td></tr>
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Description: The crystal structure of the GST-like domains complex of EPRS-AIMP2
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Kang, B.S]]
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[[http://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN]] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref> [[http://www.uniprot.org/uniprot/AIMP2_HUMAN AIMP2_HUMAN]] Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.<ref>PMID:16135753</ref>
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[[Category: Cho, H.Y]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cho, H Y]]
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[[Category: Kang, B S]]
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[[Category: Aimp2]]
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[[Category: Epr]]
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[[Category: Gst-like domain]]
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[[Category: Ligase]]

Revision as of 05:31, 22 October 2015

The crystal structure of the GST-like domains complex of EPRS-AIMP2

5a34, resolution 2.60Å

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