5bq8
From Proteopedia
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| - | ''' | + | ==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form II== |
| - | + | <StructureSection load='5bq8' size='340' side='right' caption='[[5bq8]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bq8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQ8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4my2|4my2]], [[5bpu|5bpu]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bq8 RCSB], [http://www.ebi.ac.uk/pdbsum/5bq8 PDBsum]</span></td></tr> |
| - | [[ | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Coats disease;Persistent hyperplastic primary vitreous;Norrie disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chang, T H]] | ||
[[Category: Harlos, K]] | [[Category: Harlos, K]] | ||
| - | [[Category: Jones, E | + | [[Category: Hsieh, F L]] |
| - | [[Category: | + | [[Category: Jones, E Y]] |
| + | [[Category: Cystine-knot like growth factor]] | ||
| + | [[Category: Ligand for frizzled 4 receptor]] | ||
| + | [[Category: Norrie disease protein]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Wnt signalling pathway]] | ||
Revision as of 12:28, 1 July 2015
Crystal structure of Norrin, a Wnt signalling activator, Crystal Form II
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