This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5bqx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5bqx" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Crystal structure of human STING in complex with 3'2'-cGAMP==
-
 
+
<StructureSection load='5bqx' size='340' side='right' caption='[[5bqx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
The entry 5bqx is ON HOLD
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5bqx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQX FirstGlance]. <br>
-
Authors: Wu, J., Zhang, X., Chen, Z.J., Chen, C.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4UR:32-CGAMP'>4UR</scene></td></tr>
-
 
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ksy|4ksy]]</td></tr>
-
Description: Crystal structure of human STING in complex with 3'2'-cGAMP
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bqx RCSB], [http://www.ebi.ac.uk/pdbsum/5bqx PDBsum]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
-
[[Category: Zhang, X]]
+
== Function ==
-
[[Category: Wu, J]]
+
[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
-
[[Category: Chen, Z.J]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Chen, C]]
[[Category: Chen, C]]
 +
[[Category: Chen, Z J]]
 +
[[Category: Wu, J]]
 +
[[Category: Zhang, X]]
 +
[[Category: 3'2'-cgamp]]
 +
[[Category: Immune system]]
 +
[[Category: Sting]]

Revision as of 13:05, 24 June 2015

Crystal structure of human STING in complex with 3'2'-cGAMP

5bqx, resolution 2.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5bqx"
Personal tools