3bib
From Proteopedia
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|PDB= 3bib |SIZE=350|CAPTION= <scene name='initialview01'>3bib</scene>, resolution 2.50Å | |PDB= 3bib |SIZE=350|CAPTION= <scene name='initialview01'>3bib</scene>, resolution 2.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> | + | |LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PSF:1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE'>PSF</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Timd4, Tim4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= Timd4, Tim4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2or8|2or8]], [[2or7|2or7]], [[2oyp|2oyp]], [[3bi9|3BI9]], [[3bia|3BIA]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bib OCA], [http://www.ebi.ac.uk/pdbsum/3bib PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bib RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Kaplan, G G.]] | [[Category: Kaplan, G G.]] | ||
[[Category: Santiago, C.]] | [[Category: Santiago, C.]] | ||
| - | [[Category: NA]] | ||
| - | [[Category: PSF]] | ||
[[Category: beta barrel]] | [[Category: beta barrel]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
| Line 40: | Line 41: | ||
[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:26:31 2008'' |
Revision as of 02:26, 31 March 2008
| |||||||
| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | Timd4, Tim4 (Mus musculus) | ||||||
| Related: | 2or8, 2or7, 2oyp, 3BI9, 3BIA
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Tim-4 in complex with phosphatidylserine
Overview
The T cell immunoglobulin and mucin domain (TIM) proteins are important regulators of T cell responses. Crystal structures of the murine TIM-4 identified a metal-ion-dependent ligand binding site (MILIBS) in the immunoglobulin (Ig) domain of the TIM family. The characteristic CC' loop of the TIM domain and the hydrophobic FG loop shaped a narrow cavity where acidic compounds penetrate and coordinate to a metal ion bound to conserved residues in the TIM proteins. The structure of phosphatidylserine bound to the Ig domain showed that the hydrophilic head penetrates into the MILIBS and coordinates with the metal ion, whereas the aromatic residues on the tip of the FG loop interacted with the fatty acid chains and could insert into the lipid bilayer. Our results also revealed an important role of the MILIBS in the trafficking of TIM-1 to the cell surface.
About this Structure
3BIB is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds., Santiago C, Ballesteros A, Martinez-Munoz L, Mellado M, Kaplan GG, Freeman GJ, Casasnovas JM, Immunity. 2007 Dec;27(6):941-51. PMID:18083575
Page seeded by OCA on Mon Mar 31 05:26:31 2008
