4x25
From Proteopedia
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==Structural basis for mutation-induced destabilization of Profilin 1 in ALS== | ==Structural basis for mutation-induced destabilization of Profilin 1 in ALS== | ||
<StructureSection load='4x25' size='340' side='right' caption='[[4x25]], [[Resolution|resolution]] 2.23Å' scene=''> | <StructureSection load='4x25' size='340' side='right' caption='[[4x25]], [[Resolution|resolution]] 2.23Å' scene=''> | ||
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<table><tr><td colspan='2'>[[4x25]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X25 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X25 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4x25]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X25 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X25 FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x1l|4x1l]], [[4x1m|4x1m]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x1l|4x1l]], [[4x1m|4x1m]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x25 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x25 RCSB], [http://www.ebi.ac.uk/pdbsum/4x25 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x25 OCA], [http://pdbe.org/4x25 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x25 RCSB], [http://www.ebi.ac.uk/pdbsum/4x25 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x25 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PROF1_HUMAN PROF1_HUMAN]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.<ref>PMID:18573880</ref> | [[http://www.uniprot.org/uniprot/PROF1_HUMAN PROF1_HUMAN]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.<ref>PMID:18573880</ref> | ||
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| + | ==See Also== | ||
| + | *[[Profilin|Profilin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 17:03, 22 March 2017
Structural basis for mutation-induced destabilization of Profilin 1 in ALS
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