5bmu
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S== |
| - | + | <StructureSection load='5bmu' size='340' side='right' caption='[[5bmu]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bmu]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BMU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--tRNA_ligase Glutamate--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.17 6.1.1.17] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bmu OCA], [http://pdbe.org/5bmu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bmu RCSB], [http://www.ebi.ac.uk/pdbsum/5bmu PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: Kang, B | + | [[http://www.uniprot.org/uniprot/MCA3_HUMAN MCA3_HUMAN]] Positive modulator of ATM response to DNA damage. [[http://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN]] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Glutamate--tRNA ligase]] | ||
| + | [[Category: Cho, H J]] | ||
| + | [[Category: Kang, B S]] | ||
| + | [[Category: Aimp3]] | ||
| + | [[Category: Epr]] | ||
| + | [[Category: Gst-like domain]] | ||
| + | [[Category: Translation-ligase complex]] | ||
Revision as of 05:33, 22 October 2015
The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S
| |||||||||||
