5bpq
From Proteopedia
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| - | ''' | + | ==Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form II== |
| - | + | <StructureSection load='5bpq' size='340' side='right' caption='[[5bpq]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bpq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bpq RCSB], [http://www.ebi.ac.uk/pdbsum/5bpq PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Disease == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/FZD4_HUMAN FZD4_HUMAN]] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Persistent hyperplastic primary vitreous. The disease is caused by mutations affecting the gene represented in this entry. |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FZD4_HUMAN FZD4_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chang, T H]] | ||
[[Category: Harlos, K]] | [[Category: Harlos, K]] | ||
| - | [[Category: Jones, E | + | [[Category: Hsieh, F L]] |
| - | [[Category: | + | [[Category: Jones, E Y]] |
| + | [[Category: G protein coupled receptor]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Receptor for norrin recognition]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Wnt signalling pathway]] | ||
Revision as of 12:27, 1 July 2015
Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form II
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