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5bqm
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(Difference between revisions)
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| - | ''' | + | ==Crystal structure of SXN101959, a Clostridium botulinum neurotoxin type D derivative and targeted secretion inhibitor== |
| - | + | <StructureSection load='5bqm' size='340' side='right' caption='[[5bqm]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bqm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bqm RCSB], [http://www.ebi.ac.uk/pdbsum/5bqm PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Acharya, K | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/BXD_CLOBO BXD_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '60-Lys-|-Leu-61' bond of synaptobrevins-1 and -2. [[http://www.uniprot.org/uniprot/SLIB_HUMAN SLIB_HUMAN]] GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Bontoxilysin]] | ||
| + | [[Category: Acharya, K R]] | ||
| + | [[Category: Chaddock, J A]] | ||
| + | [[Category: Davies, J R]] | ||
[[Category: Masuyer, G]] | [[Category: Masuyer, G]] | ||
| - | [[Category: | + | [[Category: Moore, K]] |
| + | [[Category: Botulinum neurotoxin]] | ||
| + | [[Category: Endopeptidase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Protein engineering]] | ||
| + | [[Category: Targeted secretion inhibitor]] | ||
| + | [[Category: Type d]] | ||
Revision as of 12:28, 20 August 2015
Crystal structure of SXN101959, a Clostridium botulinum neurotoxin type D derivative and targeted secretion inhibitor
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