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5bv3

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'''Unreleased structure'''
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==Yeast Scavenger Decapping Enzyme in complex with m7GDP==
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<StructureSection load='5bv3' size='340' side='right' caption='[[5bv3]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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The entry 5bv3 is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5bv3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BV3 FirstGlance]. <br>
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Authors: Neu, A., Neu, U., Sprangers, R.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-(N(7)-methyl_5'-triphosphoguanosine)-(mRNA)_diphosphatase 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.59 3.6.1.59] </span></td></tr>
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Description: Yeast Scavenger Decapping Enzyme in complex with m7GDP
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bv3 RCSB], [http://www.ebi.ac.uk/pdbsum/5bv3 PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Neu, U]]
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== Function ==
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[[http://www.uniprot.org/uniprot/DCPS_YEAST DCPS_YEAST]] Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP) or tri-methyl guanosine nucleoside monophosphate (m3(2,2,7)GMP), respectively. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) and tri-methylguanosine diphosphate (m3(2,2,7)GDP) to (m(7)GMP) and m3(2,2,7)GMP, respectively (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCS1 to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. May also regulates the 5'->3' exoribonucleolytic mRNA decay pathway in a cap-independent manner. Negatively regulates trehalase activity.<ref>PMID:12198172</ref> <ref>PMID:14523240</ref> <ref>PMID:15240832</ref> <ref>PMID:15273322</ref> <ref>PMID:16260594</ref> <ref>PMID:16963086</ref> <ref>PMID:22985415</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Neu, A]]
[[Category: Neu, A]]
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[[Category: Neu, U]]
[[Category: Sprangers, R]]
[[Category: Sprangers, R]]
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[[Category: Cap structure]]
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[[Category: Decapping enzyme]]
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[[Category: Hydrolase]]
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[[Category: Protein dynamic]]
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[[Category: Scavenger decapping enzyme]]
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[[Category: Substrate inhibition]]

Revision as of 14:53, 12 August 2015

Yeast Scavenger Decapping Enzyme in complex with m7GDP

5bv3, resolution 2.25Å

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