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Thiolase

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{{STRUCTURE_2iik| PDB=2iik | SIZE=400| SCENE=Thiolase/Thiolase/2 |right|CAPTION=Human 3-ketoacyl-CoA thiolase dimer, [[2iik]] }}
{{STRUCTURE_2iik| PDB=2iik | SIZE=400| SCENE=Thiolase/Thiolase/2 |right|CAPTION=Human 3-ketoacyl-CoA thiolase dimer, [[2iik]] }}
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Two different classes of '''thiolases''' are found . Degrative thiolase like '''3-ketoacyl-CoA thiolase''' (KCT) is involved in fatty acid β oxidation. Biosynthetic thiolases like '''acetoacetyl-CoA thiolase''' (ACT) are involved in the thiolysis of acetoacetyl-CoA.
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Two different classes of '''thiolases''' are found.<br />
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*'''Degrative thiolase''' like '''3-ketoacyl-CoA thiolase''' (KCT) is involved in fatty acid β oxidation<ref>PMID:16630629</ref><.<br />
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*'''Biosynthetic thiolases''' like '''acetoacetyl-CoA thiolase''' (ACT) are involved in the thiolysis of acetoacetyl-CoA<ref>PMID:21908473</ref><.
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For Bacterial Thiolase see [[Bacterial thiolase]]
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For Bacterial thiolase see [[Bacterial thiolase]]
== 3D Structures of Thiolase ==
== 3D Structures of Thiolase ==
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**[[4dd5]], [[4e1l]] – ACT – ''Clostridium difficile''<br />
**[[4dd5]], [[4e1l]] – ACT – ''Clostridium difficile''<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:09, 12 September 2016

Template:STRUCTURE 2iik

Two different classes of thiolases are found.

  • Degrative thiolase like 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid β oxidation[1]<.
  • Biosynthetic thiolases like acetoacetyl-CoA thiolase (ACT) are involved in the thiolysis of acetoacetyl-CoA[2]<.

For Bacterial thiolase see Bacterial thiolase

3D Structures of Thiolase

Updated on 12-September-2016

References

  1. ↑ Sundaramoorthy R, Micossi E, Alphey MS, Germain V, Bryce JH, Smith SM, Leonard GA, Hunter WN. The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation. J Mol Biol. 2006 Jun 2;359(2):347-57. Epub 2006 Mar 29. PMID:16630629 doi:http://dx.doi.org/10.1016/j.jmb.2006.03.032
  2. ↑ Soto G, Stritzler M, Lisi C, Alleva K, Pagano ME, Ardila F, Mozzicafreddo M, Cuccioloni M, Angeletti M, Ayub ND. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. J Exp Bot. 2011 Nov;62(15):5699-711. doi: 10.1093/jxb/err287. Epub 2011 Sep 9. PMID:21908473 doi:http://dx.doi.org/10.1093/jxb/err287

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