Tissue factor
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Function == | == Function == | ||
| - | '''Tissue factor''' (TF) is a high-affinity receptor for the blood coagulation factor VII. The TF/factor VII complex is responsible for the initiation of the coagulation protease cascade. | + | '''Tissue factor''' (TF) is a high-affinity receptor for the blood coagulation factor VII. The TF/factor VII complex is responsible for the initiation of the coagulation protease cascade<ref>PMID:23809131</ref>. |
== Disease == | == Disease == | ||
| - | + | TF is involved in cancer angiogenesis and metastasis<ref>PMID:14614019</ref>. | |
== Relevance == | == Relevance == | ||
| + | TF expression by cardiac myocytes is important to maintain heart hemostasis under normal and pathologic conditions<ref>PMID:17663739</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:04, 14 September 2016
| |||||||||||
3D structures of tissue factor
Updated on 14-September-2016
References
- ↑ Chen VM, Hogg PJ. Encryption and decryption of tissue factor. J Thromb Haemost. 2013 Jun;11 Suppl 1:277-84. doi: 10.1111/jth.12228. PMID:23809131 doi:http://dx.doi.org/10.1111/jth.12228
- ↑ Poon RT, Lau CP, Ho JW, Yu WC, Fan ST, Wong J. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res. 2003 Nov 1;9(14):5339-45. PMID:14614019
- ↑ Pawlinski R, Tencati M, Holscher T, Pedersen B, Voet T, Tilley RE, Marynen P, Mackman N. Role of cardiac myocyte tissue factor in heart hemostasis. J Thromb Haemost. 2007 Aug;5(8):1693-700. PMID:17663739 doi:http://dx.doi.org/10.1111/j.1538-7836.2007.02649.x
