Transcription initiation factor
From Proteopedia
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<StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''> | <StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''> | ||
| - | '''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process.<br /> | + | '''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br /> |
* '''TFIIA''' is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br /> | * '''TFIIA''' is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br /> | ||
| - | * '''TFIIB''' bridges between TFIID and RNA polymerase II.<br /> | + | * '''TFIIB''' bridges between TFIID and RNA polymerase II<ref>PMID:1876184</ref>.<br /> |
* '''TFIID''' recognizes the promoter sequence on the DNA.<br /> | * '''TFIID''' recognizes the promoter sequence on the DNA.<br /> | ||
| + | * '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br /> | ||
* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter. | * '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter. | ||
</StructureSection> | </StructureSection> | ||
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| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:43, 20 September 2016
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3D structures of transcription initiation factors
Updated on 20-September-2016
References
- ↑ Roeder RG. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci. 1996 Sep;21(9):327-35. PMID:8870495
- ↑ Kuhlman TC, Cho H, Reinberg D, Hernandez N. The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter. Mol Cell Biol. 1999 Mar;19(3):2130-41. PMID:10022900
- ↑ Ha I, Lane WS, Reinberg D. Cloning of a human gene encoding the general transcription initiation factor IIB. Nature. 1991 Aug 22;352(6337):689-95. PMID:1876184 doi:http://dx.doi.org/10.1038/352689a0
- ↑ Peterson MG, Inostroza J, Maxon ME, Flores O, Admon A, Reinberg D, Tjian R. Structure and functional properties of human general transcription factor IIE. Nature. 1991 Dec 5;354(6352):369-73. PMID:1956398 doi:http://dx.doi.org/10.1038/354369a0
